Table 4.
Significant KEGG Pathways (P≤0.05, Counts ≥5) Associated with 6 Breast Cancer Stem Cell-Associated Modules
| Module | Entry | Name | Count | P-value |
|---|---|---|---|---|
| hsa03013 | RNA transport | 6 | 2.87E-07 | |
| hsa03008 | Ribosome biogenesis in eukaryotes | 3 | 0.00072 | |
| Red | hsa03010 | Ribosome | 3 | 0.0022 |
| hsa03015 | mRNA surveillance pathway | 2 | 0.019 | |
| hsa04150 | mTOR signaling pathway | 2 | 0.04 | |
| hsa03040 | Spliceosome | 9 | 3.06E-14 | |
| Cyan | hsa03013 | RNA transport | 8 | 8.24E-12 |
| hsa03015 | mRNA surveillance pathway | 5 | 8.41E-08 | |
| hsa00190 | Oxidative phosphorylation | 7 | 6.50E-14 | |
| hsa04714 | Thermogenesis | 7 | 1.43E-12 | |
| hsa05012 | Parkinson’s disease | 6 | 1.71E-11 | |
| hsa05010 | Alzheimer’s disease | 6 | 0.0074 | |
| Orchid | hsa05016 | Huntington’s disease | 6 | 6.20E-11 |
| hsa04932 | Non-alcoholic fatty liver disease (NAFLD) | 5 | 2.85E-09 | |
| hsa01100 | Metabolic pathways | 7 | 5.26E-08 | |
| hsa04723 | Retrograde endocannabinoid signaling | 3 | 3.37E-05 | |
| hsa04621 | NOD-like receptor signaling pathway | 4 | 2.85E-06 | |
| hsa05164 | Influenza A | 4 | 2.85E-06 | |
| hsa05162 | Measles | 3 | 7.54E-05 | |
| hsa05152 | Tuberculosis | 3 | 0.00012 | |
| Violet | hsa04060 | Cytokine-cytokine receptor interaction | 3 | 0.00034 |
| hsa04623 | Cytosolic DNA-sensing pathway | 2 | 0.00091 | |
| hsa05140 | Leishmaniasis | 2 | 0.00091 | |
| hsa05321 | Inflammatory bowel disease (IBD) | 2 | 0.00091 | |
| hsa05132 | Salmonella infection | 2 | 0.0011 | |
| hsa04620 | Toll-like receptor signaling pathway | 2 | 0.0014 | |
| hsa05142 | Chagas disease (American trypanosomiasis) | 2 | 0.0014 | |
| hsa05145 | Toxoplasmosis | 2 | 0.0014 | |
| hsa04380 | Osteoclast differentiation | 2 | 0.0016 | |
| hsa04650 | Natural killer cell mediated cytotoxicity | 2 | 0.0016 | |
| hsa04217 | Necroptosis | 2 | 0.0022 | |
| hsa04630 | Jak-STAT signaling pathway | 2 | 0.0022 | |
| hsa05167 | Kaposi’s sarcoma-associated herpesvirus infection | 2 | 0.0026 | |
| hsa05168 | Herpes simplex infection | 2 | 0.0026 | |
| hsa05200 | Pathways in cancer | 2 | 0.0179 | |
| hsa04151 | PI3K-Akt signaling pathway | 4 | 0.00014 | |
| hsa04015 | Rap1 signaling pathway | 3 | 0.00019 | |
| Purple | hsa04062 | Chemokine signaling pathway | 3 | 0.00019 |
| hsa04360 | Axon guidance | 3 | 0.00019 | |
| hsa04611 | Platelet activation | 3 | 0.00019 | |
| hsa04630 | Jak-STAT signaling pathway | 3 | 0.00019 | |
| hsa01100 | Metabolic pathways | 15 | 2.22E-05 | |
| hsa03430 | Mismatch repair | 3 | 0.0021 | |
| hsa04950 | Maturity onset diabetes of the young | 3 | 0.0021 | |
| hsa03030 | DNA replication | 3 | 0.0028 | |
| other | hsa03410 | Base excision repair | 3 | 0.0028 |
| hsa00510 | N-Glycan biosynthesis | 3 | 0.0047 | |
| hsa03420 | Nucleotide excision repair | 3 | 0.0047 | |
| hsa05200 | Pathways in cancer | 7 | 0.0047 | |
| hsa04210 | Apoptosis | 4 | 0.0049 |