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. Author manuscript; available in PMC: 2021 Apr 28.
Published in final edited form as: Cancer Lett. 2020 Feb 12;476:87–96. doi: 10.1016/j.canlet.2020.02.004

Figure 6. Inhibition of SUV39H1 results in 5-FU-resistant tumor cell apoptosis and growth suppression in vitro.

Figure 6.

A. The 5-FU-resistant tumor cells were treated with F5446 at the indicated concentrations for 3 days. Cells were stained with annexin V and PI and analyzed by flow cytometry. Shown are representative plots of flow cytometry data (top panel). Cell death was quantified and presented at the bottom panel. The % apoptotic cell death was calculated by the formula: Annexin V+ PI+ cells in the treatment group-Annexin V+ PI+ cells in the control group. B. Tumor cells as indicated were cultured in the presence of F5446 at the indicated concentrations for three days and analyzed by MTT assay for cell viability. Shown are representative data of one of two experiments.