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. Author manuscript; available in PMC: 2020 Sep 23.
Published in final edited form as: Nat Genet. 2020 Mar 23;52(4):388–400. doi: 10.1038/s41588-020-0602-9

Extended Data Fig. 6. 4C-Seq validation of MYC super-enhancer interaction in primary T-ALL.

Extended Data Fig. 6

A) 4C-seq analysis using MYC promoter as viewpoint. Positive y-axis shows interactions with the MYC promoter viewpoint as normalized read counts, negative y-axis shows significance of differential interactions between T cells and primary T-ALL samples as log10(P value) derived using edgeR function glmQLFTest. H3K27ac ChIP-seq tracks for T cells and CUTLL1 are represented below as fold-enrichment over input. Number replicates: T cells 4C n = 2; T-ALL 1 4C n = 1; T-ALL 2 4C n = 2; T cells H3K27ac n = 2; CUTLL1 H3K27ac n = 2.