TABLE 3.
RRs (95% CIs) of each frailty criterion for a 1-SD increase in the diet score among women aged ≥60 y in the Nurses’ Health Study1
| AMED | DASH | AHEI-2010 | |
|---|---|---|---|
| Fatigue, 30,761 cases | |||
| Age-adjusted | 0.89 (0.88, 0.90) | 0.90 (0.89, 0.91) | 0.89 (0.88, 0.90) |
| Multivariable model2 | 0.89 (0.88, 0.91) | 0.91 (0.90, 0.92) | 0.90 (0.89, 0.91) |
| Multivariable model3 | 0.89 (0.87, 0.90) | 0.91 (0.90, 0.92) | 0.91 (0.89, 0.92) |
| Multivariable model4 | 0.94 (0.93, 0.96) | 0.95 (0.94, 0.96) | 0.95 (0.94, 0.96) |
| Reduced resistance, 10,955 cases | |||
| Age-adjusted | 0.78 (0.76, 0.80) | 0.86 (0.84, 0.87) | 0.86 (0.84, 0.87) |
| Multivariable model2 | 0.81 (0.79, 0.84) | 0.89 (0.88, 0.91) | 0.88 (0.86, 0.90) |
| Multivariable model3 | 0.81 (0.78, 0.83) | 0.89 (0.87, 0.90) | 0.88 (0.86, 0.90) |
| Multivariable model4 | 0.93 (0.90, 0.95) | 0.98 (0.96, 1.00) | 0.98 (0.96, 1.00) |
| Reduced aerobic capacity, 22,875 cases | |||
| Age-adjusted | 0.80 (0.79, 0.81) | 0.85 (0.84, 0.86) | 0.83 (0.82, 0.85) |
| Multivariable model2 | 0.83 (0.81, 0.84) | 0.88 (0.87, 0.89) | 0.86 (0.85, 0.87) |
| Multivariable model3 | 0.82 (0.81, 0.84) | 0.88 (0.86, 0.89) | 0.86 (0.85, 0.87) |
| Multivariable model4 | 0.93 (0.91, 0.94) | 0.96 (0.95, 0.97) | 0.94 (0.93, 0.96) |
| ≥5 illnesses, 4420 cases | |||
| Age-adjusted | 0.96 (0.93, 1.00) | 0.95 (0.92, 0.98) | 0.88 (0.85, 0.90) |
| Multivariable model2 | 0.98 (0.94, 1.02) | 0.98 (0.95, 1.01) | 0.90 (0.87, 0.93) |
| Multivariable model3 | 0.95 (0.92, 1.00) | 0.96 (0.93, 0.99) | 0.90 (0.87, 0.93) |
| Multivariable model4 | 1.01 (0.97, 1.05) | 1.00 (0.97, 1.03) | 0.93 (0.90, 0.97) |
| Weight loss, 25,277 cases | |||
| Age-adjusted | 0.92 (0.90, 0.93) | 0.94 (0.93, 0.95) | 0.93 (0.92, 0.94) |
| Multivariable model2 | 0.89 (0.87, 0.90) | 0.93 (0.91, 0.94) | 0.92 (0.90, 0.93) |
| Multivariable model3 | 0.89 (0.88, 0.91) | 0.93 (0.92, 0.94) | 0.92 (0.91, 0.93) |
| Multivariable model4 | 0.92 (0.90, 0.93) | 0.95 (0.94, 0.96) | 0.94 (0.93, 0.95) |
n = 71,941. SDs of the diet scores: AMED score SD was 2, DASH score SD was 4, AHEI-2010 score SD was 10. AHEI-2010, alternate Healthy Eating Index-2010; AMED, alternate Mediterranean diet; DASH, Dietary Approaches to Stop Hypertension.
Adjusted for age (1-y increment), BMI (<25.0, 25.0–29.9, ≥30.0 kg/m2), smoking status (never, past, and current 1–14, 15–24, and ≥25 cigarettes/d), and energy intake (kcal/d; quintiles). The DASH score is also adjusted for alcohol intake (0, 1.0–4.9, 5.0–14.9, ≥15.0 g/d).
Also adjusted for medication use (aspirin, postmenopausal hormone replacement therapy, diuretics, β-blockers, calcium channel blockers, angiotensin-converting enzyme inhibitors, other blood pressure medication, statins and other cholesterol-lowering drugs, insulin, oral hypoglycemic medication).
Also adjusted for leisure-time physical activity (MET-h/wk; quintiles).