TABLE 3.
Multivariable-adjusted OR and 95% CI for cognitive impairment according to quartiles of fat intake: the Singapore Chinese Health Study
| Quartiles of fat intake | |||||
|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | P-trend1 | |
| Total fat | |||||
| Cases/n | 674/4184 | 676/4184 | 558/4184 | 489/4184 | |
| Median,2 g/d | 33.9 (26.7–37.1) | 42.2 (40.6–43.6) | 47.7 (46.3–49.2) | 55.3 (52.7–59.4) | |
| Model 13 | 1.00 | 0.97 (0.86–1.10) | 0.83 (0.73–0.94) | 0.78 (0.68–0.89) | <0.001 |
| Model 24 | 1.00 | 1.01 (0.88–1.16) | 0.86 (0.74–1.00) | 0.80 (0.67–0.94) | 0.003 |
| SFAs | |||||
| Cases/n | 646/4184 | 645/4184 | 588/4184 | 518/4184 | |
| Median,2 g/d | 10.7 (8.64–12.0) | 14.4 (13.7–15.1) | 17.0 (16.3–17.7) | 20.7 (19.5–22.7) | |
| Model 13 | 1.00 | 1.03 (0.91–1.17) | 0.96 (0.84–1.09) | 0.93 (0.81–1.06) | 0.16 |
| Model 24 | 1.00 | 1.08 (0.94–1.25) | 1.05 (0.89–1.24) | 1.08 (0.89–1.31) | 0.51 |
| MUFAs | |||||
| Cases/n | 666/4184 | 681/4184 | 559/4184 | 491/4184 | |
| Median,2 g/d | 11.1 (8.83–12.1) | 14.1 (13.5–14.6) | 16.1 (15.6–16.7) | 19.0 (18.0–20.6) | |
| Model 13 | 1.00 | 1.01 (0.89–1.15) | 0.84 (0.73–0.95) | 0.78 (0.68–0.89) | <0.001 |
| Model 24 | 1.00 | 1.03 (0.88–1.19) | 0.85 (0.71–1.02) | 0.80 (0.64–0.99) | 0.02 |
| Model 35 | 1.00 | 1.08 (0.92–1.26) | 0.87 (0.71–1.05) | 0.77 (0.61–0.97) | 0.02 |
| PUFAs | |||||
| Cases/n | 663/4184 | 642/4184 | 553/4184 | 539/4184 | |
| Median,2 g/d | 5.95 (4.63–6.53) | 7.75 (7.37–8.10) | 9.35 (8.90–9.92) | 12.9 (11.6–14.9) | |
| Model 13 | 1.00 | 0.91 (0.80–1.04) | 0.76 (0.66–0.86) | 0.74 (0.65–0.85) | <0.001 |
| Model 24 | 1.00 | 0.99 (0.86–1.14) | 0.86 (0.74–1.01) | 0.84 (0.72–0.99) | 0.02 |
| Model 35 | 1.00 | 0.99 (0.86–1.14) | 0.85 (0.73–0.99) | 0.82 (0.70–0.95) | 0.003 |
| Animal-based fat | |||||
| Cases/n | 639/4184 | 612/4184 | 611/4184 | 535/4184 | |
| Median,2 g/d | 8.66 (6.03–10.2) | 13.2 (12.3–14.0) | 16.5 (15.6–17.4) | 21.3 (19.7–24.2) | |
| Model 13 | 1.00 | 0.93 (0.82–1.06) | 0.98 (0.86–1.12) | 0.92 (0.81–1.05) | 0.31 |
| Model 24 | 1.00 | 0.98 (0.85–1.13) | 1.04 (0.89–1.22) | 0.96 (0.81–1.15) | 0.76 |
| Plant-based fat | |||||
| Cases/n | 662/4184 | 634/4184 | 583/4184 | 518/4184 | |
| Median,2 g/d | 21.0 (17.2–23.2) | 27.2 (26.0–28.3) | 31.5 (30.3–32.6) | 38.3 (35.9–42.3) | |
| Model 13 | 1.00 | 0.91 (0.80–1.04) | 0.86 (0.75–0.98) | 0.78 (0.68–0.89) | <0.001 |
| Model 24 | 1.00 | 0.97 (0.84–1.10) | 0.91 (0.79–1.05) | 0.84 (0.72–0.98) | 0.02 |
P-trend was estimated using median values of quartiles as a continuous variable in logistic models.
Median intakes are shown as median value (IQR).
Model 1 was adjusted for age at cognition assessment, sex, educational level, marital status, dialect groups, and total energy intake.
Model 2 was further adjusted for BMI, physical activity, smoking status, alcohol consumption, sleep duration, physician-diagnosed history of diabetes, hypertension, heart disease, stroke, and cancer, and dietary intake of protein, cholesterol, and fiber (quartiles). Different types of fat were included in the model simultaneously.
Model 3 further included carbohydrate intake but excluded SFA from the model.