Figure 11.

Effects of DEHP and DiNP on levels of follicle stimulating hormone and inhibin B at 12 months post-dosing. Female CD-1 mice were orally dosed at age 39–40 days for 10 days with either vehicle control (corn oil), DEHP (20μg/kg/day – 200 mg/kg/day), or DiNP (20μg/kg/day – 200 mg/kg/day). At 12 months following completion of dosing, mice were euthanized in the diestrous stage and sera were collected. Sera samples were shipped to the University of Virginia Center for Research in Reproduction Ligand Assay and Analysis Core for analysis of follicle stimulating hormone (FSH) (control n = 12 mice/group, DEHP 20μg/kg/day – 200 mg/kg/day n = 5–6 mice/group, DiNP 20 μg/kg/day – 200 mg/kg/day n = 5–6 mice/group) (A) and inhibin B (control n = 10 mice/group, DEHP 20μg/kg/day – 200 mg/kg/day n = 4–6 mice/group, DiNP 20 μg/kg/day – 200 mg/kg/day n = 5–6 mice/group) (B) via radioimmunoassay (RIA). Data are represented as means ± standard error. Borderline statistical significance (0.05 < p ≤ 0.10) is denoted with a caret (^).