Skip to main content
. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Reprod Toxicol. 2020 Jan 2;93:28–42. doi: 10.1016/j.reprotox.2019.12.006

Figure 12.

Figure 12.

Effects of DEHP and DiNP on levels of sex steroid hormones at 15 months post-dosing. Female CD-1 mice were orally dosed at age 39–40 days for 10 days with either vehicle control (corn oil), DEHP (20μg/kg/day – 200 mg/kg/day), or DiNP (20μg/kg/day – 200 mg/kg/day). At 15 months following completion of dosing, mice were euthanized in the diestrous stage and sera were collected for analysis of testosterone (control n = 12 mice/group, DEHP 20μg/kg/day – 200 mg/kg/day n = 5–6 mice/group, DiNP 20 μg/kg/day – 200 mg/kg/day n = 4–6 mice/group) (A), progesterone (control n = 12 mice/group, DEHP 20μg/kg/day – 200 mg/kg/day n = 5–6 mice/group, DiNP 20 μg/kg/day – 200 mg/kg/day n = 4–6 mice/group) B), and estradiol (control n = 12 mice/group, DEHP 20μg/kg/day – 200 mg/kg/day n = 5–6 mice/group, DiNP 20 μg/kg/day – 200 mg/kg/day n = 4–6 mice/group) (C) via enzyme-linked immunosorbent assay (ELISA). Data are represented as means ± standard error. Borderline statistical significance (0.05 < p ≤ 0.10) is denoted with a caret (^).