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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Reprod Toxicol. 2020 Jan 2;93:28–42. doi: 10.1016/j.reprotox.2019.12.006

Figure 4.

Figure 4.

Effects of DEHP and DiNP on ovarian follicle populations at 15 months post-dosing. Female CD-1 mice were orally dosed at age 39–40 days for 10 days with either vehicle control (corn oil), DEHP (20μg/kg/day – 200 mg/kg/day), or DiNP (20μg/kg/day – 200 mg/kg/day). At 15 months following completion of the dosing period, females were euthanized and ovaries were collected and histologically evaluated for raw follicle numbers (control n = 11 mice/group, DEHP 20μg/kg/day – 200 mg/kg/day n = 5–6 mice/group, DiNP 20 μg/kg/day – 200 mg/kg/day n = 4–5 mice/group) (A), percent of follicles (control n =11 mice/group, DEHP 20μg/kg/day – 200 mg/kg/day n = 5–6 mice/group, DiNP 20 μg/kg/day – 200 mg/kg/day n = 4–5 mice/group) (B), percent of unhealthy follicles (control n = 11 mice/group, DEHP 20μg/kg/day – 200 mg/kg/day n = 5–6 mice/group, DiNP 20 μg/kg/day – 200 mg/kg/day n = 4–5 mice/group) (C), and total number of follicles (n = 4–11 mice/group) (D). Statistical significance (p ≤ 0.05) is denoted with an asterisk (*). Data are represented as means ± standard error. Borderline statistical significance (0.05 < p ≤ 0.10) is denoted with a caret (^).