Table 2:
Bone parameter post-ABX treatment
WT | KO | ||||
---|---|---|---|---|---|
C (n=14) | Post-ABX (n=17) | Post-ABX LR (n=22) | C (n=9) | Post-ABX (n=11) | |
Femur trabecular | |||||
BV/TV | 34.42 ± 2.49 | 25.25 ± 2.85 * | 30.91 ± 2.22 (^0.09) | 50.21 ± 2.72 * | 44.47 ± 2.97 |
BMD (mg/mL) | 286.7 ± 11.07 | 243.1 ± 13.15 * | 277.5 ± 11.02 | 311.1 ± 15.59 | 326.4 ± 15.26 |
BMC (mg) | 0.9532 ± 0.045 | 0.7936 ± 0.043 | 0.8895 ± 0.045 | 1.00 ± 0.077 | 1.046 ± 0.056 |
Tb. Th. (mm) | 0.058 ± 0.002 | 0.047 ± 0.002 * | 0.051 ± 0.002 | 0.067 ± 0.002 | 0.064 ± 0.004 |
Tb. N.(1/mm) | 5.87 ± 0.25 | 5.06 ± 0.34 | 5.89 ± 0.23 ^ | 7.44 ± 0.24 * | 6.92 ± 0.19 |
Tb. Sp. (mm) | 0.112 ± 0.008 | 0.1698 ± 0.005 * | 0.117 ± 0.007 ^ | 0.068 ± 0.005 | 0.081 ± 0.005 |
Femur Cortical | |||||
Ct.Ar (mm^2) | 1.01 ± 0.01 | 0.94 ± 0.02 | 0.97 ± 0.02 | 0.96 ± 0.05 | 1.00 ± 0.03 |
Ct.Th (mm) | 0.23 ± 0.005 | 0.22 ± 0.004 | 0.22 ± 0.004 | 0.23 ± 0.006 | 0.23 ± 0.009 |
Ma.Ar (mm^2) | 1.07 ± 0.04 | 1.08 ± 0.03 | 1.05 ± 0.03 | 1.03 ± 0.05 | 1.02 ± 0.04 |
Tt.Ar (mm^2) | 2.09 ± 0.04 | 2.03 ± 0.03 | 2.02 ± 0.04 | 2.00 ± 0.09 | 2.02 ± 0.07 |
Inner perimeter (mm) | 3.93 ± 0.080 | 3.99 ± 0.06 | 3.91 ± 0.06 | 3.83 ± 0.12 | 3.80 ± 0.09 |
Outer perimeter (mm) | 5.39 ± 0.05 | 5.42 ± 0.11 | 5.30 ± 0.05 | 5.25 ± 0.14 | 5.34 ± 0.14 |
BMD (mg/cc) | 964.8 ± 18.37 | 931.2 ± 18.57 | 930 ± 11.17 | 928.6 ± 21.47 | 965.4 ± 25.24 |
BMC (mg) | 0.019 ± 0.0004 | 0.017 ± 0.0005 | 0.018 ± 0.0005 | 0.018 ± 0.001 | 0.019 ± 0.001 |