Table 1.
Patient characteristics at baseline and comparing those with recurrent anal HSIL vs. no recurrent HSIL at 3 years of follow-up post treatment
| Patient characteristic | All patients (n=45) Number (%) or Mean ± SD |
Recurrence (n= 22) Number (%) or Mean ± SD |
No recurrence (n= 23) Number (%) or Mean ± SD |
P Value (recurrence vs. no recurrence) |
|---|---|---|---|---|
| Age, years | 46.0 ± 7.8 | 46.0 ± 8.2 | 46.0 ± 7.5 | 0.86 |
| Years of HIV at hHSIL Diagnosis | 14.04 ± 7.93 | 14.6 ± 8.1 | 13.6 ± 8.0 | 0.61 |
| Nadir CD4 count | ||||
| Mean | 198.4 ± 202.1 | 164.6 ± 139.7 | 230.3 ± 247.1 | |
| ≥ 200 cells/mm3 | 13 (28.9) | 5 (22.7) | 8 (34.8) | 0.72 |
| < 200 cells/mm3 | 32 (71.1) | 17 (77.3) | 15 (65.2) | 0.51 |
| CD4 at hHSIL Diagnosis | ||||
| Mean | 516.1 ± 333.2 | 504.1 ± 399.8 | 527.4 ± 266.1 | |
| ≥ 200 cells/mm3 | 33 (73.3) | 15 (68.2) | 18 (78.3) | 0.39 |
| < 200 cells/mm3 | 12 (26.7) | 7 (31.8) | 5 (21.7) | 0.51 |
| History of Genital Dysplasia | ||||
| Cervical hHSIL | 23 (51.1) | 13 (59.1) | 10 (43.5) | 0.29 |
| Vulvar hHSIL | 9 (20.0) | 6 (27.3) | 3 (13.0) | 0.28 |
| Vaginal hHSIL | 2 (4.44) | 1 (4.6) | 1 (4.4) | 1.00 |
| Genital Warts | 6 (13.33) | 0 (0.0) | 6 (26.1) | 0.02a |
| Smoking History | 0.85b | |||
| Never Smoker | 10 (22.2) | 6 (27.3) | 4 (17.4) | |
| Current Smoker | 24 (53.3) | 11 (50.0) | 13 (56.5) | |
| Past Smoker | 10 (22.2) | 5 (22.7) | 5 (21.7) | |
| Unknown | 1 (2.2) | 0 (0.0) | 1 (4.4) |
Data are presented as mean +/− standard deviation or as N (%)
a
Significant at ≤ 0.05
b
Never smoker compared with all other smoking categories
hHSIL = histologic high-grade squamous intraepithelial lesion