Table 2.
Two cases of 5-FU-related coronary spasm those we recently experienced at The Cancer Institute Hospital of Japanese Foundation for Cancer Research
| Case | Age (years) | Sex | Primary cancer | Chemotherapy regimen | Cardiotoxicity | Signs and symptoms | Diagnosis | Treatment | Onset time | Time to onset | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 62 | Male | Rectal cancer | Modified FOLFOX6 | Angina (Coronary Spasm) | Chest pain | Electrocardiography | Sublingual glyceryl trinitrate | Course 1 day 2 | 24–35 h | The chemotherapy regimen was changed → irinotecan monotherapy |
| High blood pressure | Nicorandil | ||||||||||
| 2 | 77 | Female | Rectal cancer | FOLFIRI plus bevacizumab | Angina (Coronary Spasm) | Chest pain | Electrocardiography | Sublingual glyceryl trinitrate | Course 1 day 2 | 36 h | The chemotherapy regimen was changed → S-1 + irinotecan + bevacizumab |
| High blood pressure |