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. 2020 Apr 7;3:165. doi: 10.1038/s42003-020-0898-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Venn diagram depicting common and unique binding sites among AFF4 and H3K27ac cistromes in MCF7 cells. b, c Global positive correlation between AFF4 and H3K27ac cistromes. Aggregation plots (top) and corresponding heatmaps (bottom) of AFF4 and H3K27ac cistromes in MCF7 cells after hierarchical clustering. Binding sites are either aligned relative to the AFF4/H3K27Ac peak center (b) or relative to the transcription start site (TSS) and transcription termination site (TES) of AFF4/ H3K27ac -bound genes (c). d IGV tracks showing the colocalization of AFF4 and H3K27ac peaks on transcription start site (TSS) of ESR1 gene. e A magnified figure of the rectangle shown in d.