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. 2020 Apr 7;11:1729. doi: 10.1038/s41467-020-15537-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a AAV2-CAG-FLEX-tdTomato was unilaterally injected into the PVH of Ntrk2^CreER/+ mice (a1). After the mice were treated with tamoxifen, tdTomato-labeled PVH^TrkB neurons were present throughout the rostral-caudal axis (a2–a4). Axonal terminals of these neurons were found in the VMH, LPBN, MPBN, LC, NTS and DMV (a5–a8). b The LPBN includes the external (e), central (c), and ventral (v) compartments. Axonal terminals of PVH^TrkB neurons are mainly in the central compartment, which is next to the CGRP-marked external compartment. c, d Retrograde tracers, CTB488 (250 nl) or GRB (200 nl), were unilaterally injected into the VMH (c) or LPBN (d) of tamoxifen-treated Ntrk2^CreER/+;Rosa26^Ai9/+ mice and labeled some tdTomato-expressing PVH^TrkB neurons. AP area postrema; DMV dorsal motor nucleus of the vagus; ME median eminence; LC locus coeruleus; LPBN lateral parabrachial nucleus; MPBN medial parabrachial nucleus; NTS nucleus tractus solitaris; PVH paraventricular hypothalamus; scp superior cerebellar peduncle; VMH ventromedial hypothalamus. Scale bars represent 200 μm in d1 and 50 μm in other panels. Source data are provided as a Source Data file.