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. 2020 Apr 7;10:5995. doi: 10.1038/s41598-020-62879-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Genotypes of produced lambs for OTOF mutations using the CRISPR/Cas9 technology. Blue color, exon 5; Red color, exon 6; HO, homozygous; HE, heterozygous; slash (/), separates the genotypes of the two chromosomes; WT, wild-type; KO, knockout; Del, deletion; KI, insertion of STOP codons; PTC, premature termination codon due to NHEJ leading to a KO. In bold all the mutations that induce a KO. All DNA samples were extracted from skin except #63 and #66 (skin and muscle), #97 (skin, muscle and blood).