Table S1. Cox regression analysis of associations prognostic factors and DSS in the unmatched cohort.
| Characteristic | Univariate | Multivariate | |||
|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | ||
| Year of diagnosis (year) | |||||
| 2004–2006 | Reference | ||||
| 2007–2009 | 1.100 (0.858–1.409) | 0.453 | |||
| 2010–2013 | 0.872 (0.671–1.132) | 0.303 | |||
| Age group | |||||
| 37–64 years | Reference | ||||
| 65–73 years | 1.226 (0.963–1.562) | 0.099 | 1.185 (0.930–1.510) | 0.171 | |
| 74–96 years | 1.548 (1.221–1.964) | <0.001 | 1.389 (1.088–1.774) | 0.008 | |
| Insurance status | |||||
| None | Reference | ||||
| Yes | 1.438 (0.461–4.486) | 0.532 | |||
| Unknown | 1.474 (0.468–4.644) | 0.508 | |||
| Sex | |||||
| Male | Reference | ||||
| Female | 0.703 (0.578–0.856) | <0.001 | 0.675 (0.554–0.822) | <0.001 | |
| Race | |||||
| Black | Reference | ||||
| White | 1.163 (0.814–1.663) | 0.407 | |||
| Others | 0.820 (1.351–1.351) | 0.437 | |||
| Cost–of–living index | |||||
| ≤1 | Reference | ||||
| >1 | 0.895 (0.735–1.089) | 0.266 | |||
| Marital status | |||||
| Single | Reference | ||||
| Married | 0.965 (0.686–1.355) | 0.835 | |||
| Divorced/separated | 0.988 (0.652–1.496) | 0.953 | |||
| Others | 1.057 (0.724–1.544) | 0.775 | |||
| Laterality | |||||
| Right | Reference | ||||
| Left | 1.049 (0.859–1.281) | 0.638 | |||
| Lobe | |||||
| Upper | Reference | ||||
| Middle | 0.757 (0.490–1.170) | 0.211 | |||
| Lower | 1.017 (0.815–1.269) | 0.883 | |||
| Others/unknown | 0.896 (0.334–2.405) | 0.827 | |||
| Differentiation | |||||
| Well | Reference | ||||
| Moderate | 1.394 (0.992–1.958) | 0.056 | NS | ||
| Poor | 1.269 (0.886–1.818) | 0.194 | NS | ||
| Unknown | 0.961 (0.492–1.876) | 0.907 | NS | ||
| Pathological type | |||||
| Adenocarcinoma | Reference | ||||
| Squamous carcinoma | 1.205 (0.942–1.541) | 0.139 | |||
| Lymphadenectomy/Biopsy | |||||
| None | Reference | ||||
| Yes | 0.453 (0.360–0.570) | <0.001 | 0.621 (0.464–0.830) | 0.001 | |
| Number of LNs sampled | |||||
| None/unknown | Reference | ||||
| 1–3 | 0.701 (0.527–0.933) | 0.015 | NS | ||
| 4–6 | 0.540 (0.403–0.723) | <0.001 | NS | ||
| 7–9 | 0.569 (0.416–0.777) | <0.001 | NS | ||
| 10–12 | 0.524 (0.355–0.773) | 0.001 | NS | ||
| ≥13 | 0.381 (0.266–0.546) | <0.001 | NS | ||
| Radiation | |||||
| None/unknown | Reference | ||||
| Yes | 2.057 (1.400–3.021) | <0.001 | 1.706 (1.151–2.530) | 0.008 | |
| Chemotherapy | |||||
| None/unknown | Reference | ||||
| Yes | 0.948 (0.704–1.275) | 0.722 | |||
| Surgery | |||||
| Sub | Reference | ||||
| Lob | 0.513 (0.418–0.628) | <0.001 | 0.702 (0.538–0.915) | 0.009 | |
HRs are only reported on multivariate analysis if they remained significant. DSS, disease-specific survival; Sub, sublobectomy; Lob, lobectomy; LN, lymph node; HR, Hazard ratio; CIs, confidence intervals; NS, not significant.