Table S2. Cox regression analysis of associations prognostic factors and OS in the unmatched cohort.
| Characteristic | Univariate | Multivariate | |||
|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | ||
| Year of diagnosis (year) | |||||
| 2004–2006 | Reference | ||||
| 2007–2009 | 1.022 (0.839–1.245) | 0.831 | |||
| 2010–2013 | 0.901 (0.731–1.110) | 0.326 | |||
| Age group (year) | |||||
| 37–64 | Reference | ||||
| 65–73 | 1.449 (1.186–1.771) | <0.001 | 1.366 (1.116–1.672) | 0.003 | |
| 74–96 | 2.178 (1.799–2.637) | <0.001 | 1.870 (1.532–2.283) | <0.001 | |
| Insurance status | |||||
| None | Reference | ||||
| Yes | 1.288 (0.533–3.111) | 0.574 | |||
| Unknown | 1.343 (0.552–3.268) | 0.516 | |||
| Sex | |||||
| Male | Reference | ||||
| Female | 0.709 (0.606–0.828) | <0.001 | 0.677 (0.578–0.793) | <0.001 | |
| Race | |||||
| Black | Reference | ||||
| White | 1.131 (0.857–1.493) | 0.385 | NS | ||
| Others | 0.619 (0.408–0.939) | 0.024 | NS | ||
| Cost–of–living index | |||||
| ≤1 | Reference | ||||
| >1 | 0.884 (0.756–1.033) | 0.122 | |||
| Marital status | |||||
| Single | Reference | ||||
| Married | 0.884 (0.677–1.154) | 0.365 | |||
| Divorced/separated | 0.932 (0.672–1.294) | 0.675 | |||
| Others | 1.119 (0.835–1.500) | 0.452 | |||
| Laterality | |||||
| Right | Reference | ||||
| Left | 1.000 (0.853–1.174) | 0.996 | |||
| Lobe | |||||
| Upper | Reference | ||||
| Middle | 0.871 (0.630–1.205) | 0.405 | |||
| Lower | 0.969 (0.810–1.158) | 0.726 | |||
| Others/unknown | 1.045 (0.495–2.207) | 0.908 | |||
| Differentiation | |||||
| Well | Reference | ||||
| Moderate | 1.202 (0.930–1.554) | 0.161 | |||
| Poor | 1.109 (0.844–1.457) | 0.457 | |||
| Unknown | 0.880 (0.524–1.476) | 0.627 | |||
| Pathological type | |||||
| Adenocarcinoma | Reference | ||||
| Squamous carcinoma | 1.453 (1.207–1.750) | <0.001 | 1.237 (1.023–1.496) | 0.028 | |
| Lymphadenectomy/biopsy | |||||
| None | Reference | ||||
| Yes | 0.446 (0.371–0.535) | <0.001 | 0.696 (0.500–0.968) | 0.031 | |
| Number of LNs sampled | |||||
| None/unknown | Reference | ||||
| 1–3 | 0.657 (0.522–0.826) | <0.001 | 0.969 (0.706–1.330) | 0.845 | |
| 4–6 | 0.544 (0.433–0.684) | <0.001 | 0.856 (0.620–1.183) | 0.346 | |
| 7–9 | 0.585 (0.459–0.746) | <0.001 | 0.947 (0.675–1.327) | 0.751 | |
| 10–12 | 0.405 (0.289–0.567) | <0.001 | 0.694 (0.461–1.045) | 0.080 | |
| ≥13 | 0.379 (0.286–0.502) | <0.001 | 0.640 (0.444–0.923) | 0.017 | |
| Radiation | |||||
| None/unknown | Reference | ||||
| Yes | 1.578 (1.122–2.219) | 0.009 | NS | ||
| Chemotherapy | |||||
| None/unknown | Reference | ||||
| Yes | 0.793 (0.618–1.019) | 0.070 | NS | ||
| Surgery | |||||
| Sub | Reference | ||||
| Lob | 0.507 (0.432–0.597) | <0.001 | 0.787 (0.629–0.985) | 0.037 | |
HRs are only reported on multivariate analysis if they remained significant. OS, overall survival; Sub, sublobectomy; Lob, lobectomy; LN, lymph node; HR, Hazard ratio; CIs, confidence intervals; NS, not significant.