Table S3. Cox regression analysis of associations prognostic factors and DSS in the PSM cohort.
| Characteristic | Univariate | Multivariate | |||
|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | ||
| Year of diagnosis (year) | |||||
| 2004–2006 | Reference | ||||
| 2007–2009 | 1.184 (0.780–1.797) | 0.427 | |||
| 2010–2013 | 0.764 (0.491–1.189) | 0.233 | |||
| Age group (year) | |||||
| 37–64 | Reference | ||||
| 65–73 | 1.535 (1.004–2.346) | 0.048 | 1.639 (1.065–2.521) | 0.025 | |
| 74–96 | 1.736 (1.145–2.632) | 0.009 | 1.913 (1.245–2.938) | 0.003 | |
| Insurance status | |||||
| None | Reference | ||||
| Yes | / | / | |||
| Unknown | / | / | |||
| Sex | |||||
| Male | Reference | ||||
| Female | 0.675 (0.485–0.938) | 0.019 | 0.694 (0.495–0.973) | 0.034 | |
| Race | |||||
| Black | Reference | ||||
| White | 1.453 (0.783–2.695) | 0.236 | |||
| Others | 1.051 (0.446–2.477) | 0.909 | |||
| Cost-of-living index | |||||
| ≤1 | Reference | ||||
| >1 | 0.832 (0.597–1.161) | 0.279 | |||
| Marital status | |||||
| Single | Reference | ||||
| Married | 1.010 (0.581–1.754) | 0.972 | |||
| Divorced/separated | 1.141 (0.564–2.308) | 0.715 | |||
| Others | 1.044 (0.565–1.929) | 0.890 | |||
| Laterality | |||||
| Right | Reference | ||||
| Left | 1.017 (0.727–1.423) | 0.921 | |||
| Lobe | |||||
| Upper | Reference | ||||
| Middle | 1.046 (0.528–2.073) | 0.898 | |||
| Lower | 1.059 (0.731–1.534) | 0.764 | |||
| Others/unknown | 0.000 (0.000–Inf) | 0.994 | |||
| Differentiation | |||||
| Well | Reference | ||||
| Moderate | 1.693 (0.978–2.931) | 0.060 | NS | ||
| Poor | 1.388 (0.767–2.513) | 0.279 | NS | ||
| Unknown | 0.274 (0.036–2.077) | 0.210 | NS | ||
| Pathological type | |||||
| Adenocarcinoma | Reference | ||||
| Squamous carcinoma | 1.086 (0.714–1.651) | 0.701 | |||
| Lymphadenectomy/biopsy | |||||
| None | Reference | ||||
| Yes | 0.477 (0.324–0.701) | <0.001 | 0.491 (0.331–0.728) | <0.001 | |
| Number of LNs sampled | |||||
| None/Unknown | Reference | ||||
| 1–3 | 0.974 (0.656–1.445) | 0.895 | NS | ||
| 4–6 | 0.569 (0.345–0.940) | 0.028 | NS | ||
| 7–9 | 0.485 (0.230–1.023) | 0.058 | NS | ||
| 10–12 | 0.734 (0.332–1.621) | 0.444 | NS | ||
| ≥13 | 0.358 (0.153–0.837) | 0.018 | NS | ||
| Radiation | |||||
| None/unknown | Reference | ||||
| Yes | 2.431 (1.397–4.231) | 0.001 | 2.275 (1.285–4.028) | 0.005 | |
| Chemotherapy | |||||
| None/unknown | Reference | ||||
| Yes | 1.283 (0.807–2.041) | 0.293 | |||
| Surgery | |||||
| Sub | Reference | ||||
| Lob | 0.597 (0.427–0.835) | 0.003 | 0.689 (0.490–0.968) | 0.032 | |
HRs are only reported on multivariate analysis if they remained significant. PSM, propensity score matching; DSS, disease-specific survival; Sub, sublobectomy; Lob, lobectomy; LN, lymph node; HR, Hazard ratio; CIs, confidence intervals; NS, not significant.