Table S4. Cox regression analysis of associations prognostic factors and OS in the PSM cohort.
| Characteristic | Univariate | Multivariate | |||
|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | ||
| Year of diagnosis (year) | |||||
| 2004–2006 | Reference | ||||
| 2007–2009 | 1.191 (0.849–1.671) | 0.311 | |||
| 2010–2013 | 0.807 (0.564–1.156) | 0.243 | |||
| Age group (year) | |||||
| 37–64 | Reference | ||||
| 65–73 | 1.538 (1.077–2.198) | 0.018 | 1.744 (1.210–2.514) | 0.003 | |
| 74–96 | 2.177 (1.556–3.046) | <0.001 | 2.219 (1.567–3.142) | <0.001 | |
| Insurance status | |||||
| None | Reference | ||||
| Yes | / | / | |||
| Unknown | / | / | |||
| Sex | |||||
| Male | Reference | ||||
| Female | 0.620 (0.475–0.808) | <0.001 | 0.589 (0.448–0.775) | <0.001 | |
| Race | |||||
| Black | Reference | ||||
| White | 1.620 (0.972–2.700) | 0.064 | NS | ||
| Others | 0.805 (0.374–1.736) | 0.581 | NS | ||
| Cost-of-living index | |||||
| ≤1 | Reference | ||||
| >1 | 1.000 (0.766–1.305) | 1.000 | |||
| Marital status | |||||
| Single | Reference | ||||
| Married | 0.862 (0.568–1.309) | 0.487 | |||
| Divorced/separated | 0.807 (0.452–1.439) | 0.468 | |||
| Others | 0.930 (0.583–1.483) | 0.760 | |||
| Laterality | |||||
| Right | Reference | ||||
| Left | 0.889 (0.676–1.170) | 0.403 | |||
| Lobe | |||||
| Upper | Reference | ||||
| Middle | 1.219 (0.727–2.043) | 0.454 | |||
| Lower | 1.010 (0.744–1.371) | 0.950 | |||
| Others/unknown | 1.063 (0.338–3.338) | 0.917 | |||
| Differentiation | |||||
| Well | Reference | ||||
| Moderate | 1.425 (0.932–2.177) | 0.102 | |||
| Poor | 1.352 (0.859–2.126) | 0.192 | |||
| Unknown | 0.488 (0.148–1.612) | 0.239 | |||
| Pathological type | |||||
| Adenocarcinoma | Reference | ||||
| Squamous carcinoma | 1.171 (0.841–1.631) | 0.349 | |||
| Lymphadenectomy/biopsy | |||||
| None | Reference | ||||
| Yes | 0.524 (0.381–0.721) | <0.001 | 0.575 (0.414–0.798) | 0.001 | |
| Number of LNs sampled | |||||
| None/Unknown | Reference | ||||
| 1–3 | 0.916 (0.661–1.270) | 0.599 | NS | ||
| 4–6 | 0.716 (0.491–1.044) | 0.083 | NS | ||
| 7–9 | 0.6027 (0.2194–1.0491) | 0.073 | NS | ||
| 10–12 | 0.476 (0.219–1.034) | 0.061 | NS | ||
| ≥13 | 0.373 (0.192–0.723) | 0.004 | NS | ||
| Radiation | |||||
| None/unknown | Reference | ||||
| Yes | 1.838 (1.118–3.022) | 0.016 | 2.101 (1.260–3.503) | 0.004 | |
| Chemotherapy | |||||
| None/unknown | Reference | ||||
| Yes | 0.892 (0.583–1.364) | 0.597 | |||
| Surgery | |||||
| Sub | Reference | ||||
| Lob | 0.619 (0.473–0.810) | <0.001 | 0.723 (0.549–0.953) | 0.021 | |
HRs are only reported on multivariate analysis if they remained significant. PSM, propensity score matching; OS, overall survival; Sub, sublobectomy; Lob, lobectomy; LN, lymph node; HR, hazard ratio; CIs, confidence intervals; NS, not significant.