Table S5. Cox regression analysis of associations prognostic factors and DSS in the IPTW cohort.
| Characteristic | Univariate | Multivariate | |||
|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | ||
| Year of diagnosis (year) | |||||
| 2004–2006 | Reference | ||||
| 2007–2009 | 1.079 (0.912–1.277) | 0.374 | 0.92 (0.775–1.101) | 0.3751 | |
| 2010–2013 | 0.845 (0.706–1.010) | 0.065 | 0.776 (0.645–0.935) | 0.008 | |
| Age group (year) | |||||
| 37–64 | Reference | ||||
| 65–73 | 1.385 (1.171–1.638) | <0.001 | 1.371 (1.152–1.631) | <0.001 | |
| 74–96 | 1.364 (1.145–1.625) | <0.001 | 1.481 (1.223–1.794) | <0.001 | |
| Insurance status | |||||
| None | Reference | ||||
| Yes | 2.124 (0.764–5.905) | 0.149 | |||
| Unknown | 2.213 (0.792–6.185) | 0.130 | |||
| Sex | |||||
| Male | Reference | ||||
| Female | 0.573 (0.500–0.656) | <0.001 | 0.553 (0.476–0.643) | <0.001 | |
| Race | |||||
| Black | Reference | ||||
| White | 1.626 (1.283–2.060) | <0.001 | 1.862 (1.443–2.404) | <0.001 | |
| Others | 0.555 (0.388–0.794) | 0.001 | 0.657 (0.442–0.977) | 0.038 | |
| Cost-of-living index | |||||
| ≤1 | Reference | ||||
| >1 | 1.010 (0.879–1.160) | 0.892 | |||
| Marital status | |||||
| Single | Reference | ||||
| Married | 0.824 (0.643–1.056) | 0.126 | |||
| Divorced/separated | 0.773 (0.570–1.048) | 0.098 | |||
| Others | 0.848 (0.642–1.121) | 0.247 | |||
| Laterality | |||||
| Right | Reference | ||||
| Left | 1.072 (0.933–1.233) | 0.326 | |||
| Lobe | |||||
| Upper | Reference | ||||
| Middle | 0.420 (0.288–0.613) | <0.001 | |||
| Lower | 0.712 (0.608–0.835) | <0.001 | |||
| Others/unknown | 0.302 (0.119–0.767) | 0.012 | |||
| Differentiation | |||||
| Well | Reference | ||||
| Moderate | 1.908 (1.499–2.428) | <0.001 | 1.735 (1.350–2.229) | <0.001 | |
| Poor | 1.442 (1.119–1.859) | 0.005 | 1.534 (1.175–2.003) | 0.002 | |
| Unknown | 0.727 (0.396–1.334) | 0.303 | 0.646 (0.349–1.195) | 0.163 | |
| Pathological type | |||||
| Adenocarcinoma | Reference | ||||
| Squamous carcinoma | 1.384 (1.166–1.644) | <0.001 | |||
| Lymphadenectomy/biopsy | |||||
| None | Reference | ||||
| Yes | 0.470 (0.401–0.551) | <0.001 | 0.463 (0.345–0.620) | <0.001 | |
| Number of LNs sampled | |||||
| None/unknown | Reference | ||||
| 1–3 | 0.713 (0.584–0.871) | <0.001 | NS | ||
| 4–6 | 0.540 (0.438–0.666) | <0.001 | NS | ||
| 7–9 | 0.540 (0.438–0.666) | 0.002 | NS | ||
| 10–12 | 0.484 (0.359–0.654) | <0.001 | NS | ||
| ≥13 | 0.447 (0.360–0.556) | <0.001 | NS | ||
| Radiation | |||||
| None/unknown | Reference | ||||
| Yes | 1.059 (0.782–1.436) | 0.710 | |||
| Chemotherapy | |||||
| None/unknown | Reference | ||||
| Yes | 0.813 (0.658–1.004) | 0.054 | NS | ||
| Surgery | |||||
| Sub | Reference | ||||
| Lob | 0.825 (0.720–0.946) | 0.006 | 0.765 (0.665–0.882) | <0.001 | |
HRs are only reported on multivariate analysis if they remained significant. IPTW, inverse probability of treatment weighted; DSS, disease-specific survival; Sub, sublobectomy; Lob, lobectomy; LN, lymph node; HR, hazard ratio; CIs, confidence intervals; NS, not significant.