Table S6. Cox regression analysis of associations prognostic factors and OS in the IPTW cohort.
| Characteristic | Univariate | Multivariate | |||
|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | ||
| Year of diagnosis (year) | |||||
| 2004–2006 | Reference | ||||
| 2007–2009 | 0.979 (0.849–1.128) | 0.765 | |||
| 2010–2013 | 1.030 (0.890–1.192) | 0.691 | |||
| Age group (year) | |||||
| 37–64 | Reference | ||||
| 65–73 | 1.456 (1.269–1.671) | <0.001 | 1.518 (1.314–1.753) | <0.001 | |
| 74–96 | 1.974 (1.719–2.267) | <0.001 | 1.833 (1.572–2.138) | <0.001 | |
| Insurance status | |||||
| None | Reference | ||||
| Yes | 1.895 (0.865–4.151) | 0.110 | |||
| Unknown | 1.773 (0.806–3.904) | 0.155 | |||
| Sex | |||||
| Male | Reference | ||||
| Female | 0.576 (0.517–0.643) | <0.001 | 0.562 (0.498–0.634) | <0.001 | |
| Race | |||||
| Black | Reference | ||||
| White | 1.960 (1.605–2.393) | <0.001 | 2.112 (1.706–2.613) | <0.001 | |
| Others | 0.450 (0.327–0.620) | <0.001 | 0.561 (0.394–0.800) | 0.001 | |
| Cost-of-living index | |||||
| ≤1 | Reference | ||||
| >1 | 0.737 (0.657–0.827) | <0.001 | NS | ||
| Marital status | |||||
| Single | Reference | ||||
| Married | 0.655 (0.545–0.788) | <0.001 | 0.627 (0.518–0.758) | <0.001 | |
| Divorced/separated | 0.551 (0.434–0.701) | <0.001 | 0.612 (0.475–0.789) | <0.001 | |
| Others | 0.746 (0.606–0.917) | <0.001 | 0.699 (0.560–0.871) | 0.001 | |
| Laterality | |||||
| Right | Reference | ||||
| Left | 0.943 (0.807–1.102) | 0.460 | |||
| Lobe | |||||
| Upper | Reference | ||||
| Middle | 0.545 (0.416–0.713) | <0.001 | 0.659 (0.495–0.879) | 0.005 | |
| Lower | 0.706 (0.621–0.802) | <0.001 | 0.867 (0.758–0.992) | 0.037 | |
| Others/unknown | 0.526 (0.295–0.940) | 0.030 | 0.631 (0.351–1.134) | 0.124 | |
| Differentiation | |||||
| Well | Reference | ||||
| Moderate | 1.570 (1.309–1.883) | <0.001 | 1.420 (1.171–1.721) | <0.001 | |
| Poor | 1.252 (1.034–1.515) | 0.021 | 1.406 (1.145–1.726) | 0.001 | |
| Unknown | 0.944 (0.628–1.419) | 0.781 | 0.842 (0.555–1.277) | 0.419 | |
| Pathological type | |||||
| Adenocarcinoma | Reference | ||||
| Squamous carcinoma | 1.529 (1.337–1.749) | <0.001 | 1.178 (1.023–1.356) | 0.022 | |
| Lymphadenectomy/biopsy | |||||
| None | Reference | ||||
| Yes | 0.511 (0.448–0.583) | <0.001 | 0.569 (0.454–0.713) | <0.001 | |
| Number of LNs sampled | |||||
| None/unknown | Reference | ||||
| 1–3 | 0.687 (0.583–0.810) | <0.001 | NS | ||
| 4–6 | 0.582 (0.493–0.687) | <0.001 | NS | ||
| 7–9 | 0.894 (0.758–1.054) | 0.184 | NS | ||
| 10–12 | 0.376 (0.287–0.493) | <0.001 | NS | ||
| ≥13 | 0.418 (0.350–0.499) | <0.001 | NS | ||
| Radiation | |||||
| None/unknown | Reference | ||||
| Yes | 0.846 (0.647–1.105) | 0.220 | |||
| Chemotherapy | |||||
| None/unknown | Reference | ||||
| Yes | 0.601 (0.499–0.724) | <0.001 | NS | ||
| Surgery | |||||
| Sub | Reference | ||||
| Lob | 0.796(0.714–0.888) | <0.001 | 0.724(0.646–0.812) | <0.001 | |
HRs are only reported on multivariate analysis if they remained significant. IPTW, inverse probability of treatment weighted; OS, overall survival; Sub, sublobectomy; Lob, lobectomy; LN, lymph node; HR, Hazard ratio; CIs, confidence intervals; NS, not significant.