Table 3. Summary of pooled ORs in the meta-analysis and FPRP.
| Ethnicity | N † | Allelic model | Heterozygote model | Homozygote model | Dominant model | Recessive model | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR | I2 (%) | FPRP‡ | OR | I2 (%) | FPRP | OR | I2 (%) | FPRP | OR | I2 (%) | FPRP | OR | I2 (%) | FPRP | ||||||
| MMP1 -1607 1G/2G | ||||||||||||||||||||
| Asian | 2 | 1.34 (1.18–1.53) | 0.0 | 0.002 | 1.23 (0.93–1.63) | 0.0 | – | 1.73 (1.29–2.31) | 0.0 | 0.107 | 1.45 (1.11–1.89) | 0.0 | 0.498 | 1.45 (1.21–1.74) | 0.0 | 0.010 | ||||
| Caucasian | 4 | 1.00 (0.93–1.09) | 0.0 | – | 1.06 (0.93–1.21) | 0.0 | – | 1.01 (0.87–1.18) | 0.0 | – | 1.04 (0.92–1.18) | 0.0 | – | 0.97 (0.85–1.10) | 0.0 | – | ||||
| Total | 6 | 1.12 (0.97–1.29) | 70.0 | – | 1.09 (0.97–1.23) | 0.0 | – | 1.22 (0.95–1.58) | 61.6 | – | 1.11 (0.99–1.24) | 31.8 | – | 1.13 (0.92–1.39) | 67.2 | – | ||||
| MMP2 -1306 C/T | ||||||||||||||||||||
| Asian | 2 | 0.53 (0.43–0.64) | 0.0 | 0.000 | 0.48 (0.39–0.60) | 0.0 | 0.000 | 0.46 (0.23–0.93) | 0.0 | 0.953 | 0.48 (0.39–0.59) | 0.0 | 0.000 | 0.55 (0.27–1.10) | 0.0 | – | ||||
| Caucasian | 1 | 1.04 (0.60–1.79) | – | – | 0.97 (0.51–1.81) | – | – | 2.00 (0.18–22.65) | – | – | 1.00 (0.54–1.86) | – | – | 2.02 (0.18–22.71) | – | – | ||||
| Total | 3 | 0.64 (0.44–0.93) | 64.1 | 0.821 | 0.58 (0.39–0.87) | 56.6 | 0.770 | 0.52 (0.27–1.02) | 0.0 | – | 0.59 (0.39–0.89) | 61.2 | 0.808 | 0.61 (0.31–1.18) | 0.0 | – | ||||
| MMP2 -735 C/T | ||||||||||||||||||||
| Asian | 2 | 0.76 (0.66–0.87) | 31.1 | 0.007 | 0.72 (0.51–1.01) | 69.4 | – | 0.74 (0.50–1.09) | 0.0 | – | 0.72 (0.53–0.97) | 64.1 | 0.814 | 0.84 (0.57–1.24) | 0.0 | – | ||||
| Caucasian | 1 | 0.87 (0.47–1.62) | – | – | 0.83 (0.41–1.70) | – | – | 0.97 (0.13–7.09) | – | – | 0.84 (0.42–1.68) | – | – | 1.01 (0.14–7.34) | – | – | ||||
| Total | 3 | 0.76 (0.66–0.88) | 0.0 | 0.024 | 0.73 (0.56–0.95) | 43.1 | 0.717 | 0.75 (0.51–1.10) | 0.0 | – | 0.73 (0.58–0.92) | 34.9 | 0.493 | 0.85 (0.58–1.24) | 0.0 | – | ||||
| MMP3 -1171 5A/6A | ||||||||||||||||||||
| Asian | 1 | 0.96 (0.71–1.30) | – | – | 0.79 (0.28–2.29) | – | – | 0.79 (0.28–2.21) | – | – | 0.79 (0.28–2.20) | – | – | 0.97 (0.69–1.38) | – | – | ||||
| Caucasian | 2 | 0.99 (0.91–1.08) | 0.0 | – | 1.02 (0.88–1.19) | 0.0 | – | 0.98 (0.83–1.16) | 0.0 | – | 1.01 (0.88–1.16) | 0.0 | – | 0.97 (0.85–1.11) | 0.0 | – | ||||
| Total | 3 | 0.99 (0.91–1.07) | 0.0 | – | 1.02 (0.88–1.18) | 0.0 | – | 0.98 (0.83–1.15) | 0.0 | – | 1.01 (0.88–1.15) | 0.0 | – | 0.97 (0.86–1.10) | 0.0 | – | ||||
| MMP7 -181 A/G | ||||||||||||||||||||
| Asian | 3 | 1.89 (1.41–2.54) | 29.7 | 0.037 | 1.92 (1.40–2.63) | 0.0 | 0.072 | 4.11 (0.67–25.80) | 0.0 | – | 1.98 (1.44–2.70) | 2.0 | 0.038 | 3.81 (0.61–23.86) | 0.0 | – | ||||
| Total | 3 | 1.89 (1.41–2.54) | 29.7 | – | 1.92 (1.40–2.63) | 0.0 | – | 4.11 (0.67–25.80) | 0.0 | – | 1.98 (1.44–2.70) | 2.0 | – | 3.81 (0.61–23.86) | 0.0 | – | ||||
| MMP9 -1562 C/T | ||||||||||||||||||||
| Asian | 1 | 0.68 (0.43–1.08) | – | – | 0.72 (0.42–1.23) | – | – | 0.30 (0.05–1.82) | – | – | 0.68 (0.40–1.15) | – | – | 0.33 (0.05–1.99) | – | – | ||||
| Caucasian | 2 | 0.83 (0.67–1.02) | 0.0 | – | 0.98 (0.77–1.24) | 0.0 | – | 0.27 (0.12–0.62) | 0.0 | 0.924 | 0.89 (0.71–1.12) | 0.0 | – | 0.27 (0.12–0.62) | 0.0 | 0.924 | ||||
| Total | 3 | 0.80 (0.67–0.97) | 0.0 | 0.704 | 0.93 (0.75–1.16) | 0.0 | – | 0.28 (0.13–0.59) | 0.0 | 0.878 | 0.86 (0.69–1.05) | 0.0 | – | 0.28 (0.13–0.59) | 0.0 | 0.878 | ||||
| MMP9 R279Q | ||||||||||||||||||||
| Asian | 2 | 0.88 (0.76–1.02) | 45.5 | – | 0.71 (0.32–1.56) | 69.8 | – | 0.73 (0.52–1.03) | 0.0 | – | 0.69 (0.33–1.45) | 68.9 | – | 0.78 (0.55–1.07) | 0.0 | – | ||||
| Total | 2 | 0.88 (0.76–1.02) | 45.5 | – | 0.71 (0.32–1.56) | 69.8 | – | 0.73 (0.52–1.03) | 0.0 | – | 0.69 (0.33–1.45) | 68.9 | – | 0.78 (0.55–1.07) | 0.0 | – | ||||
| MMP12 -82A/G | – | |||||||||||||||||||
| Asian | 2 | 0.78 (0.47–1.32) | 0.0 | – | 0.78 (0.46–1.32) | 0.0 | – | – | – | – | 0.78 (0.46–1.32) | 0.0 | – | – | – | – | ||||
| Caucasian | 1 | 0.98 (0.84–1.13) | – | – | 1.02 (0.86–1.21) | – | – | 0.76 (0.45–1.29) | – | – | 1.00 (0.85–1.18) | – | – | 0.75 (0.44–1.28) | – | – | ||||
| Total | 3 | 0.96 (0.83–1.11) | 0.0 | – | 0.99 (0.85–1.17) | 0.0 | – | 0.76 (0.45–1.29) | – | – | 0.98 (0.84–1.14) | 0.0 | – | 0.75 (0.44–1.28) | – | – | ||||
| MMP13 -77A/G | ||||||||||||||||||||
| Asian | 2 | 0.88 (0.72–1.08) | 46.7 | – | 0.67 (0.47–0.96) | 45.3 | 0.849 | 0.76 (0.50–1.16) | 49.5 | – | 0.70 (0.48–1.01) | 55.3 | – | 1.01 (0.80–1.27) | 0.0 | – | ||||
| Caucasian | 1 | 1.10 (0.91–1.34) | – | – | 1.14 (0.88–1.47) | – | – | 1.15 (0.73–1.82) | – | – | 1.14 (0.89–1.46) | – | – | 1.09 (0.70–1.69) | – | – | ||||
| Total | 3 | 0.95 (0.79–1.14) | 59.4 | – | 0.81 (0.54–1.22) | 78.3 | – | 0.87 (0.61–1.24) | 51.1 | – | 0.83 (0.56–1.23) | 78.3 | – | 1.02 (0.83–1.26) | 0.0 | – | ||||
†, N number of included studies; ‡, FPRP false-positive report probabilities (power OR =1.5, prior probability =0.01).