Table S1. Positive results from the sensitivity analysis.

Study omitted	Allelic model				Heterozygote model				Homozygote model				Dominant model				Recessive model
	OR (95% CI)	P	I2 (%)		OR (95% CI)	P	I2 (%)		OR (95% CI)	P	I2 (%)		OR (95% CI)	P	I2 (%)		OR (95% CI)	P	I2 (%)
MMP1 -1607 1G/2G
Su													1.17 (1.00–1.38)	0.050	36.5
Gonzalez-Arriaga													1.15 (1.02–1.30)	0.023	14.3
Hart													1.09 (0.96–1.23)	0.171	41.4
Liu													1.07 (0.95–1.20)	0.272	18.3
Fakhoury													1.11 (0.99–1.24)	0.079	45.4
Zhang													1.08 (0.97–1.22)	0.167	23.1
Combined													1.11 (0.99–1.24)	0.077	31.8
MMP2 -1306 C/T
Yu	0.86 (0.58–1.29)	0.479	54.0		0.87 (0.54–1.38)	0.546	53.3		0.69 (0.25–1.87)	0.467	0.0		0.86 (0.53–1.37)	0.517	56.3
Rollin	0.67 (0.43–1.05)	0.082	78.4		0.66 (0.38–1.16)	0.153	81.6		0.49 (0.26–0.94)	0.030	0.0		0.65 (0.38–1.12)	0.118	81.0
Bayramoglu	0.64 (0.44–0.93)	0.020	64.1		0.58 (0.39–0.86)	0.007	56.6		0.52 (0.27–1.02)	0.055	0.0		0.59 (0.39–0.89)	0.011	61.2
Song	0.81 (0.46–1.41)	0.452	84.4		0.79 (0.40–1.55)	0.486	85.2		0.57 (0.30–1.10)	0.096	0.0		0.79 (0.40–1.53)	0.479	85.4
Combined	0.74 (0.49–1.11)	0.142	76.8		0.72 (0.44–1.16)	0.176	77.8		0.55 (0.30–1.00)	0.051	0.0		0.71 (0.44–1.14)	0.160	78.2
MMP2 -735 C/T
Zhou	0.86 (0.68–1.10)	0.228	0.0		0.87 (0.65–1.16)	0.340	0.0						0.86 (0.65–1.13)	0.266	0.0
Rollin	0.76 (0.66–0.87)	0.000	31.1		0.72 (0.51–1.01)	0.061	69.4						0.72 (0.53–0.97)	0.032	64.1
Jia	0.72 (0.61–0.85)	0.000	0.0		0.63 (0.52–0.78)	0.000	0.0						0.65 (0.53–0.79)	0.000	0.0
Combined	0.76 (0.66–0.88)	0.000	0.0		0.73 (0.56–0.95)	0.019	43.1						0.73 (0.58–0.92)	0.007	34.9
MMP9 -1562 C/T
Zhang	0.80 (0.66–0.97)	0.021	0.0						0.29 (0.14–0.62)	0.002	0.0						0.30 (0.14–0.64)	0.002	0.0
Rollin	1.12 (0.56–2.23)	0.758	91.4						0.75 (0.13–4.29)	0.746	80.8						0.69 (0.15–3.20)	0.641	75.2
Bayramoglu	1.12 (0.54–2.34)	0.758	91.0						0.61 (0.07–5.02)	0.644	82.7						0.56 (0.08–3.74)	0.552	78.6
Gonzalez-Arriaga	1.05 (0.43–2.56)	0.923	90.5						0.60 (0.06–6.44)	0.673	77.7						0.58 (0.07–4.79)	0.612	72.0
Combined	1.00 (0.57–1.75)	0.988	87.9						0.53 (0.11–2.53)	0.426	75.1						0.51 (0.13–2.07)	0.348	68.8
MMP9 R279Q
Hu													0.42 (0.18–0.97)	0.041	–
Zhao													0.92 (0.75–1.13)	0.424	–
Combined													0.69 (0.33–1.45)	0.330	68.9
MMP13 -77A/G
Gonzalez-Arriaga					0.67 (0.47–0.96)	0.029	45.3
Wang					0.96 (0.68–1.37)	0.838	64.1
Peng					0.80 (0.39–1.64)	0.548	88.5
Combined					0.81 (0.54–1.22)	0.312	78.3