Table 4. Clinical characteristics of the 163 patients followed up for at least 3 years, compared according to whether or not they experienced recurrence.
Characteristic | Total (n=163) | 3-y recurrence (n=62) | No 3-y recurrence (n=101) | P |
---|---|---|---|---|
Age (y) | 59.9±10.2 | 62.3±9.8 | 58.4±10.2 | 0.019 |
Age ≥60 years | 87 (53.4) | 43 (69.4) | 44 (43.6) | 0.001 |
Female | 115 (70.6) | 40 (64.5) | 75 (74.3) | 0.185 |
BMI (kg/m2) | 20.7±2.4 | 20.7±2.2 | 20.6±2.6 | 0.798 |
Current or past smoker | 29 (17.8) | 10 (16.1) | 19 (18.8) | 0.664 |
Previous history of TB treatment | 56 (34.4) | 24 (38.7) | 32 (31.7) | 0.359 |
Previous history of NTM treatment | 8 (4.9) | 7 (11.3) | 1 (1.0) | 0.005 |
Comorbidity | ||||
COPD | 20 (12.3) | 7 (11.3) | 13 (12.9) | 0.765 |
Diabetes mellitus | 15 (9.2) | 6 (9.7) | 9 (8.9) | 0.869 |
Chronic liver disease | 13 (8.0) | 5 (8.1) | 8 (7.9) | >0.999 |
Malignancy | 33 (20.2) | 13 (21.0) | 20 (19.8) | 0.857 |
Etiology | 0.701 | |||
Mycobacterium avium | 82 (50.3) | 30 (48.4) | 52 (51.5) | |
Mycobacterium intracellulare | 81 (49.7) | 32 (51.6) | 49 (48.5) | |
Positive AFB smear at treatment initiation | 45 (27.6) | 19 (30.6) | 26 (25.7) | 0.497 |
Number of involved lobes | 3.4±1.3 | 3.7±1.4 | 3.3±1.2 | 0.043 |
Use of injectable aminoglycosides | 58 (35.6) | 19 (30.6) | 39 (38.6) | 0.302 |
Daily therapy | 163 (100.0) | 62 (100.0) | 101 (100.0) | – |
Surgical resection | 4 (2.5) | 3 (4.8) | 1 (1.0) | 0.154 |
Shorter treatment duration (9–11 months) | 43 (26.4) | 18 (29.0) | 25 (24.8) | 0.547 |
Time to initiate treatment after diagnosis (months) | 4.2 (1.6–10.7) | 4.1 (1.1–11.8) | 4.3 (1.8–10.4) | 0.783 |
Follow-up duration after treatment completion (months) | 68.5 (52.4–89.6) | 67.6 (52.5–83.7) | 69.1 (51.5–90.7) | 0.828 |
BMI, body mass index; TB, tuberculosis; NTM, nontuberculous mycobacteria; COPD, chronic obstructive lung disease; AFB, acid-fast bacilli. Data are presented as mean (± standard deviation), median (interquartile range), or number (%).