Table S1. Toxicities during paclitaxel therapy in ECOG PS 2 vs. ECOG PS 0–1 patients.

Toxicities§	All grades, n [%]				CTC grade 3/4, n [%]
	ECOG PS 2	ECOG PS 0–1	P value+		ECOG PS 2	ECOG PS 0–1	P value+
Any toxicity	22 [63]	86 [62]	0.91		5 [14]	23 [16.5]	0.74
Fatigue	11 [31]	35 [25]	0.56		3 [9]	6 [4]	0.31
Polyneuropathy	6 [17]	26 [13]	0.83		0	3 [2]	0.38
Arthralgia/Myalgia	6 [17]	22 [11]	0.85		0	3 [2]	0.38
Any hematotoxicity	5 [14]	22 [11]	0.82		1 [3]	9 [6]	0.41
Leukocytopenia	3 [9]	9 [6]	0.66		1 [3]	6 [4]	0.67
Anemia	1 [3]	10 [7]	0.35		0	1 [0.7]	0.61
Thrombocytopenia	1 [3]	4 [3]	0.99		0	2 [1]	0.48
Pancytopenia	0	2 [1]	0.48		0	1 [0.7]	0.61
Nausea/vomiting	4 [11]	21 [15]	0.56		2 [6]	4 [3]	0.41
Hepatotoxicity	1 [3]	6 [4]	0.67		0	2 [1]	0.48
Allergic reaction	2 [6]	4 [3]	0.41		0	1 [0.7]	0.61

^§, data available for n=35 ECOG PS 2 patients and n=139 ECOG PS 0–1 patients; ⁺, comparison of toxicity rates between ECOG PS 2 patients and ECOG PS 0–1 patients with Chi-Square.