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Silencing of PLAT leads to reduction in proliferation in vivo. PC9R cells transfected with shNEG or shPLAT-1 were injected into nude mice. (A) Tumor volume was measured every week; (B) tumors were weighed after sacrificing; (C,D) immunohistochemical staining of Ki67 was performed on tumor samples, and positive cells were quantified. n=6 in shNEG group and n=5 in shPLAT-1 group. *, P<0.05 vs. control.
