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. 2020 Mar;12(3):712–723. doi: 10.21037/jtd.2019.12.106

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2020 Journal of Thoracic Disease. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Silence of PLAT induces apoptosis of PC9R cells through TNF-α signaling. (A) PC9R cells transfected with shNEG or shPLAT-1 were analyzed by whole human cDNA array; (B,C) the expression of TNF-α in shNEG, shPLAT-1, and shPLAT-2 cells incubated with gefitinib was measured by (B) RT-qPCR and (C) ELISA; (D) the protein levels of TNF-α, FADD, cleaved caspase-8, and caspase-8 were measured by western blotting. Each data point represents the mean ± SD of three independent experiments. *, P<0.05 vs. control.