Table 1. Patient characteristics in the total studies population and of group 1 (CKD-V) in comparison to group 2 (CKD-III).
| Characteristic | Both groups (N=60) | CKD-V (N=30) | CKD-III (N=30) | P value |
|---|---|---|---|---|
| Age (years) | 63 (52, 72.5) | 55.5 [45, 63] | 69 [62, 74] | <0.001 |
| Male (%) | 70 | 80 | 60 | |
| Body mass index (kg/m2) | 27.2 (24, 29.4) | 25.6 (23.8, 27.5) | 28.2 (25.7, 31.1) | 0.036 |
| Serum a-Klotho (pg/mL) | 548 [332, 835] | 390 [280, 590] | 722 [501, 897] | 0.001 |
| Coronary arteries CS | 503 [44, 1,200] | 697 [47, 1,400] | 299 [41, 1,200] | 0.394 |
| LMS CS | 1.5 [0, 81] | 9 [0, 111] | 0 [0, 27] | 0.382 |
| LAD CS | 131 [10, 505] | 196 [15, 560] | 129 [10, 407] | 0.579 |
| LCx CS | 76.5 [0, 250] | 111 [0, 322] | 38 [0, 174] | 0.641 |
| RCA CS | 41 [0, 466] | 42 [0, 471] | 40 [0, 399] | 0.856 |
| Aortic valve CS | 21 [0, 139] | 28 [0, 136] | 11.5 [0, 141] | 0.714 |
| 25 (OH) D (ng/mL) | 20.5 (13.8, 25.8) | 19.4 (13.5, 28.1) | 20.8 (15.2, 24.18) | 0.848 |
| Calcitonin (pg/mL) | 10.1 (4, 55.3) | 55.3 (13.5, 136) | 4.3 (1.7, 8.7) | <0.001 |
| Estimated glomerular filtration rate (mL/min/1.73 m2)* | 19.6 (5.9, 41) | 5.9 (5.1, 7.6) | 41 (35.4, 45) | <0.001 |
| Total cholesterol (mg/dL) | 160 [135, 189] | 146 [128, 170] | 172 [156, 202] | 0.004 |
| LDL cholesterol (mg/dL) | 86 [64, 106] | 69.5 [59, 92] | 92.5 [72, 111] | 0.004 |
| Calcium (mg/dL) | 9.18 (8.77, 9.51) | 9.01 (8.37, 9.37) | 9.35 (8.87, 9.67) | 0.031 |
| Phosphate (mg/dL) | 3.9 (3.3, 4.75) | 4.75 (4, 5.6) | 3.35 (2.9, 3.8) | <0.001 |
| Calcium X Phosphate product (mg2/dL2) | 35 (29.6, 41) | 41 (35.1, 49.2) | 31.5 (28.6, 35) | <0.001 |
| Total protein (gr/dL) | 7.02 (6.61, 7.35) | 6.81 (6.54, 7.35) | 7.08 (6.76, 7.38) | 0.318 |
| Albumin (gr/dL) | 4.28 (4.05, 4.56) | 4.13 (3.97, 4.52) | 4.38 (4.18, 4.6) | 0.096 |
| PTH (pmol/L) | 11.6 (7.05, 28.4) | 28.4 (15, 44.6) | 7.05 (4.3, 10.2) | <0.001 |
| TSH (ìIU/mL) | 2.5 (1.48, 3.48) | 1.9 (1.34, 3.99) | 2.5 (2.2, 3.23) | 0.679 |
| FT3 (pmol/L) | 3.95 (3.3, 4.65) | 4.15 (3.6, 4.8) | 3.8 (2.5, 4.4) | 0.05 |
| FT4 (pmol/L) | 14.9 (12.6, 17.8) | 14.9 (12.8, 17.6) | 14.8 (12.5, 18.9) | 0.745 |
| Hemoglobin (gr/dL) | 11.9 (10.8, 13.3) | 11.1 (10.5, 12) | 12.9 (11.9, 14.1) | <0.001 |
| HTN (%) | 83.3 | 86.7 | 80 | 0.731 |
| Hyperlipidemia (%) | 51.7 | 53.3 | 50 | 1 |
| DM (%) | 38.4 | 16.6 | 60 | <0.001 |
Values for continuous variables represent median (25th, 75th percentile). *, calculated with the Modification of Diet in Renal Disease study equation. CS, calcium score; LMS, left main stem; LAD, left anterior descending artery; LCx, left circumflex artery; RCA, right coronary artery; 25 (OH) D, 25 hydroxyvitamin D; PTH, parathyroid hormone; TSH, thyroid-stimulating hormone; FT3, free triiodothyronine; FT4, thyroxine; HTN, hypertension; DM, diabetes mellitus.