Table 1. Patients characteristics and the comparison between RSI <13 and RSI ≥13.
| Variable | Total (n=151) | RSI <13 (n=110) | RSI ≥13 (n=41) | P |
|---|---|---|---|---|
| Baseline characteristics | ||||
| Age (years), mean ± SD | 64.1±8.8 | 63.6±8.7 | 65.1±8.9 | 0.351 |
| Sex (male), n (%) | 136 (90.1) | 99 (90.0) | 37 (90.2) | 1.000 |
| Neoadjuvant treatment (yes), n (%) | 43 (28.5) | 31 (28.2) | 12 (29.3) | 0.895 |
| Squamous cell carcinoma | 143 (94.7) | 105 (95.5) | 38 (92.7) | 0.684 |
| Clinical stage, n (%) | ||||
| T category | 0.512 | |||
| cT1 | 69 (45.7) | 50 (45.5) | 19 (46.3) | |
| cT2 | 53 (35.1) | 41 (37.3) | 12 (29.3) | |
| cT3 | 29 (19.2) | 19 (17.3) | 10 (24.4) | |
| N category | 0.580 | |||
| cN0 | 101 (66.9) | 75 (68.2) | 26 (63.4) | |
| cN+ | 50 (33.1) | 35 (31.8) | 15 (36.6) | |
| Preoperative body weight (kg), mean ± SD | 63.3±10.6 | 63.7±10.6 | 62.4±10.5 | 0.509 |
| Preoperative BMI (kg/m2), mean ± SD | 22.9±3.2 | 23.1±3.1 | 22.5±3.5 | 0.326 |
| Operative variables | ||||
| Anastomosis, n (%) | 0.072 | |||
| Cervical | 89 (58.9) | 60 (54.5) | 29 (70.7) | |
| Thoracic | 62 (41.1) | 50 (45.5) | 12 (29.3) | |
| Esophagectomy, n (%) | 0.834 | |||
| Minimally invasive approach | 90 (59.6) | 65 (59.1) | 25 (61.0) | |
| Thoracotomy approach | 61 (40.4) | 45 (40.9) | 16 (39.0) | |
| Conduit, n (%) | 0.087 | |||
| Stomach | 144 (95.4) | 107 (97.3) | 37 (90.2) | |
| Colon | 7 (4.6) | 3 (2.7) | 4 (9.8) | |
| Lymph node dissection, n (%) | ||||
| Recurrent laryngeal lymph node dissection | 124 (82.1) | 94 (85.5) | 36 (87.8) | 0.710 |
| Three-field lymph node dissection | 34 (22.5) | 18 (16.4) | 16 (39.0) | 0.003 |
| Route of conduit reconstruction, n (%) | 0.034 | |||
| Posterior mediastinum | 143 (94.7) | 107 (97.3) | 36 (87.8) | |
| Retrosternal | 8 (5.3) | 3 (2.7) | 5 (12.2) | |
| Postoperative complications, n (%) | ||||
| Vocal cord palsy | 38 (25.1) | 19 (17.3) | 17 (41.5) | 0.002 |
| Anastomotic leak | 11 (7.3) | 10 (9.1) | 1 (2.4) | 0.290 |
| Complete resection | 147 (97.3) | 107 (97.3) | 40 (97.6) | 1.000 |
| Follow-up data | ||||
| Time after esophagectomy (month) | 29.7±23.0 | 33.1±22.5 | 20.5±22.1 | <0.001 |
| Time after esophagectomy <2 years, n (%) | 81 (53.6) | 51 (46.4) | 30 (73.2) | 0.003 |
| Time after esophagectomy ≥2 years, n (%) | 70 (46.4) | 59 (53.6) | 11 (26.8) | |
| Postoperative body weight (kg), mean ± SD | 55.8±9.5 | 56.8±9.4 | 53.1±9.0 | 0.032 |
| Postoperative BMI (kg/m2), mean ± SD | 20.3±2.9 | 20.7±2.8 | 19.3±3.0 | 0.010 |
| % change in body weight*, mean ± SD | −11.6±8.4 | −10.5±7.9 | −14.6±9.2 | 0.007 |
| % change in BMI, mean ± SD | −11.0±8.8 | −10.0±8.3 | −13.7±9.5 | 0.021 |
| Endoscopic finding, n (%) | ||||
| Reflux esophagitis | 3 (2.0) | 3 (2.7) | 0 (0.0) | 0.563 |
| Anastomosis stenosis | 14 (9.3) | 10 (9.1) | 4 (9.8) | 1.000 |
| History of dilatation | 8 (5.3) | 5 (4.5) | 3 (7.3) | 0.684 |
| Radiologic finding, n (%) | ||||
| Pneumonic infiltration | 8 (5.3) | 2 (1.8) | 6 (14.6) | 0.005 |
| Disease status, n (%) | 1.000 | |||
| No evidence of disease | 141 (93.4) | 103 (93.6) | 38 (92.7) | |
| Recurrence on treatment | 10 (6.6) | 7 (6.4) | 3 (7.3) |
*, % change of body weight = (postoperative body weight-preoperative body weight)/preoperative body weight ×100. Continuous variables are presented as means with standard deviation. BMI, body mass index; RSI, reflux symptom index.