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. 2020 Mar 25;23(4):101008. doi: 10.1016/j.isci.2020.101008

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© 2020 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

The HOTAIR CNE Represents a Poised Enhancer in HOTAIR-Nonexpressing Stem Cells in Human and Mouse

(A) Average DNase I hypersensitive site (DHS) signals around HOTAIR CNE in HOTAIR-expressing and HOTAIR-nonexpressing cells (embryonic stem cells and differentiated cells). The y axis is normalized DHS coverage in reads per million (RPM). “N” denotes the number of cell lines.

(B) The distribution of H3K4me1, H3K27me3, H3K27ac, and p300 signals around HOTAIR CNE in H9-hESC (human) and iPSC (mouse) cell lines. The y axis is normalized coverage in reads per million (RPM).

(C) A genome browser view with transcription factors, DHS, histone modifications, and RNA-seq tracks from H1-hESC cell line. HOTAIR is not expressed in H1-hESC (as shown by lack of RNA-seq reads) and marked by broad H3K27me3 peak. H3K27me3 signal is depleted around CNE, reflecting a nucleosome-depleted region and bound by multiple transcription factors.