Figure 3.

Constructs of X-polymer Nanoparticles

(A) Construct of modified 3WJ structure. (B) Constructs of the T-p sequence composed of the 3WJ sequence (blue) and CD28Apt-dimer, the two skeleton sequences except the 3WJ sequence in the nonfunctional region (orange), the TRS sequence (green), and four Del60 aptamers. (C) Construct of self-assembled X-polymer nanoparticles. The X-polymer assembly consists of one CD28Apt-dimer and four Del60 aptamers. There are two base complementary regions of Del60 on 3WJ-2Del60 and Del60-3WJ, respectively. The secondary structure diagrams of CD28Apt-dimer aptamer and Del60 aptamer are drawn with RNA structure 5.7 software (black).