Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Apr 2;19:1536012120913693. doi: 10.1177/1536012120913693

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

PMC Copyright notice

Figure 7. — Detecting a single cell at various spatial resolutions. In (A) we see the results of imaging a 10-micron diameter cell in healthy tissue with some noise and a tumor to background ratio of 10.4. We can still determine the location of the cell at the center of the imager as long as the signal to noise ratio (SNR) is greater than 10. Detecting a single cell does not require subcellular resolution contingent on the notion that the single cells are sparsely distributed and have a large tumor to background ratio. In (B) we see the SNR over a range of pixel sizes for 10 randomly generated samples given a tumor to background ratio (TBR) of 10.4. In (C) we plot the largest pixel that can detect a single cell at a given TBR with SNR greater than 10. The plot is not smooth because it is based on randomly generated samples with arbitrary noise.