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. 2020 Apr 3;18(2):1559325820913785. doi: 10.1177/1559325820913785

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© The Author(s) 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — MicroRNA-429 directly targets Cxcl1 in OGD/R-treated BMECs. A, Comparison of the sequences of miR-429 and Cxcl1. B, The fluorescence intensity of Cxcl1-WT and miR-429 mimic cotransected cells was markedly declined, **P < .01, while the fluorescence intensity of Cxcl1-MUT and miR-429 mimic cotransected cells was almost unchanged. C, The mRNA level of Cxcl1 in sham group, OGD/R-treated group, miR-429 mimic group, and miR-429 inhibitor group. **P < .01 versus the sham group, ^## P < .01 versus the OGD/R-treated group. D and E, The protein level of Cxcl1 in sham group, OGD/R-treated group, miR-429 mimic group, and miR-429 inhibitor group. **P < .01, ^## P < .01. BMECs indicates microvascular endothelial cells; mRNA, messenger RNA; MUT, mutant; OGD/R, oxygen glucose deprivation/reoxygenation; WT, wild-type.