Figure 6.

Impaired Angiogenesis and Vascular Remodeling in Mfn2^cKO Mice

(A) Experimental approach.

(B) Top views of reconstructed vascular networks. Arrowheads point to the lesion track. Insets: zooms of the lesioned core region (circled in white). Scale bar, 200 μm.

(C) Pipeline used for vasculature quantification. Scale bar, 30 μm.

(D) Vascular network analysis (n = 3 mice/condition; two-way ANOVA followed by Tukey’s post hoc test).

(E) Experimental protocol for EdU labeling. Lower pictures: views of injured cortices. Scale bar, 200 μm.

(F) Magnification showing the presence of proliferating endothelial cells (CD31⁺/ERG+).

(G) Quantification of proliferating ERG+ cells at 7 days post-SW (n = 4–5 mice/condition; nonparametric Mann-Whitney t test). ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001.

See also Figures S6 and S7.