Table 7.
Concordance between tumors seen in humans and animals for 60 Group 1 agents by organ and tissue system and tumor site.
| Number of agents |
||||
|---|---|---|---|---|
| Organ and tissue systema Tumor sitea |
Humans | Animals | Both | Overlapb (%) |
| Upper aerodigestive tract | 9 | 9 | 4 | 29 |
| Nasal cavity and paranasal sinuses | 3 | 3 | 0 | 0 |
| Nasopharynx | 3 | 1 | 1 | 33 |
| Oral cavity | 4 | 6 | 2 | 25 |
| Pharynx | 2 | 0 | 0 | N/A |
| Tongue | 0 | 1 | 0 | N/A |
| Salivary gland | 1 | 0 | 0 | N/A |
| Respiratory system | 21 | 22 | 16 | 59 |
| Larynx | 3 | 1 | 1 | 33 |
| Lung | 20 | 22 | 16 | 62 |
| Mesothelium | 2 | 2 | 2 | 100 |
| Mesothelium | 2 | 2 | 2 | 100 |
| Digestive tract | 6 | 6 | 2 | 20 |
| Oesophagus | 5 | 0 | 0 | N/A |
| Stomach | 3 | 5 | 1 | 14 |
| Intestine (including colon and rectum) | 3 | 1 | 0 | 0 |
| Digestive organs | 8 | 14 | 4 | 22 |
| Liver parenchyma and bile ducts | 7 | 14 | 4 | 24 |
| Pancreas NOS | 2 | 0 | 0 | N/A |
| Gall bladder | 1 | 0 | 0 | N/A |
| Nervous system and eye | 2 | 0 | 0 | N/A |
| Brain and spinal cord (CNS) | 1 | 0 | 0 | N/A |
| Eye | 1 | 0 | 0 | N/A |
| Endocrine system | 2 | 3 | 2 | 67 |
| Thyroid, follicular epithelium | 2 | 2 | 2 | 100 |
| Adrenal gland (medulla, cortex, NOS) | 0 | 1 | 0 | N/A |
| Pituitary gland | 0 | 1 | 0 | N/A |
| Kidney | 3 | 5 | 2 | 33 |
| Kidney (renal cortex, renal medulla, kidney NOS) | 3 | 5 | 2 | 33 |
| Urothelium | 10 | 7 | 7 | 70 |
| Urothelium (renal pelvis, ureter, or bladder) | 10 | 7 | 7 | 70 |
| Lymphoid and hematopoietic tissues | 12 | 10 | 7 | 47 |
| Hematopoietic tissues | 10 | 2 | 2 | 20 |
| Lymphoid tissue | 2 | 10 | 1 | 9 |
| Skin | 11 | 16 | 7 | 35 |
| Skin and adnexa | 9 | 16 | 6 | 32 |
| Cutaneous melanocytes | 3 | 0 | 0 | N/A |
| Connective tissues | 6 | 14 | 6 | 43 |
| Soft connective tissue | 0 | 9 | 0 | N/A |
| Blood vasculature (endothelium) | 1 | 0 | 0 | N/A |
| Hard connective tissue (bone, cartilage) | 5 | 5 | 4 | 67 |
| Female breast, female reproductive organs, and female reproductive tract | 8 | 9 | 4 | 31 |
| Breast | 4 | 8 | 2 | 20 |
| Ovary | 3 | 1 | 0 | 0 |
| Uterine cervix | 3 | 2 | 1 | 25 |
| Uterus (38) | 2 | 2 | 1 | 33 |
| Vulva/vagina | 1 | 0 | 0 | N/A |
| Other groupings | 2 | 4 | 0 | 0 |
| All cancers combined | 1 | 0 | 0 | N/A |
| All solid cancers | 1 | 0 | 0 | N/A |
| Exocrine glands NOS | 0 | 4 | 0 | N/A |
CNS, central nervous system; N/A, not applicable: assigned to sites/systems when overlap is not possible (positive data are available in either humans or animals, but not in both); NOS, not otherwise specified.
aSystems/sites in the anatomically based tumor nomenclature system (see Table 2) that lack sufficient evidence in both humans and animals not shown. For example, there were insufficient data on tumors of the male reproductive tract in both humans and animals.
bPercentage overlap calculated as [Nb/(Nh + Na − Nb)]×100%, where Nh, Na, and Nb denote the number of agents with sufficient evidence of carcinogenicity in humans, animals, or both humans and animals, respectively.