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. 2020 Apr 7;323(13):1277–1285. doi: 10.1001/jama.2020.1943

Table 4. Risk of All-Cause (Follow-up Until December 31, 2017) and Cause-Specific (Follow-up Until December 31, 2016) Mortality in Patients With Celiac Disease and Their Siblings.

All-cause mortality Cardiovascular disease Cancer Respiratory disease Other cause of death
Celiac disease Siblings Celiac disease Siblings Celiac disease Siblings Celiac disease Siblings Celiac disease Siblings
No. 32 558 56 442 32 494 56 340 32 494 56 340 32 494 56 340 32 494 56 340
Deaths, No. (%) 1580 (4.9) 2696 (4.8) 310 (1.0) 643 (1.1) 564 (1.7) 939 (1.) 79 (0.2) 124 (0.2) 486 (1.5) 759 (1.3)
Follow-up, y
Total 445 951 771 317 415 745 720 669 415 745 720 669 415 745 720 669 415 745 720 669
Mean (SD) 13.7 (8.2) 13.7 (8.3) 12.8 (8.2) 12.8 (8.3) 12.8 (8.2) 12.8 (8.3) 12.8 (8.2) 12.8 (8.3) 12.8 (8.2) 12.8 (8.3)
Median (IQR) 12.5
(7.0-19.3)
12.6
(6.8-19.4)
11.6
(6.1-18.4)
11.7
(5.9-18.5)
11.6
(6.1-18.4)
11.7
(5.9-18.5)
11.6
(6.1-18.4)
11.7
(5.9-18.5)
11.6
(6.1-18.4)
11.7
(5.9-18.5)
Incidence rate per 1000 person-years (95% CI) 3.5
(3.4-3.7)
3.5
(3.4-3.6)
0.7
(0.7-0.8)
0.9
(0.8-1.0)
1.4
(1.2-1.5)
1.3
(1.2-1.4)
0.2
(0.1-0.2)
0.2
(0.1-0.2)
1.2
(1.1-1.3)
1.1
(1.0-1.1)
Hazard ratio (95% CI)
Conditioneda 1.30 (1.22-1.39) 1.09 (0.94-1.26) 1.36 (1.22-1.53) 1.55 (1.14-2.11) 1.32 (1.17-1.49)
Adjusted Ib 1.21 (1.13-1.30) 1.05 (0.91-1.23) 1.27 (1.13-1.43) 1.40 (1.01-1.95) 1.16 (1.01-1.32)
Adjusted IIc 1.26 (1.17-1.35) 1.13 (0.96-1.33) 1.26 (1.11-1.42) 1.64 (1.15-2.34) 1.24 (1.08-1.43)
a

Indicates conditioned on family.

b

Indicates conditioned on family and further adjusted for education, Nordic country of birth, and time-dependent medical comorbidities (type 1 diabetes, autoimmune thyroid disease, rheumatoid arthritis, and inflammatory bowel disease).

c

Indicates conditioned on Adjusted I criteria and further adjusted for age and sex.