Table 4. Risk of All-Cause (Follow-up Until December 31, 2017) and Cause-Specific (Follow-up Until December 31, 2016) Mortality in Patients With Celiac Disease and Their Siblings.
All-cause mortality | Cardiovascular disease | Cancer | Respiratory disease | Other cause of death | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Celiac disease | Siblings | Celiac disease | Siblings | Celiac disease | Siblings | Celiac disease | Siblings | Celiac disease | Siblings | |
No. | 32 558 | 56 442 | 32 494 | 56 340 | 32 494 | 56 340 | 32 494 | 56 340 | 32 494 | 56 340 |
Deaths, No. (%) | 1580 (4.9) | 2696 (4.8) | 310 (1.0) | 643 (1.1) | 564 (1.7) | 939 (1.) | 79 (0.2) | 124 (0.2) | 486 (1.5) | 759 (1.3) |
Follow-up, y | ||||||||||
Total | 445 951 | 771 317 | 415 745 | 720 669 | 415 745 | 720 669 | 415 745 | 720 669 | 415 745 | 720 669 |
Mean (SD) | 13.7 (8.2) | 13.7 (8.3) | 12.8 (8.2) | 12.8 (8.3) | 12.8 (8.2) | 12.8 (8.3) | 12.8 (8.2) | 12.8 (8.3) | 12.8 (8.2) | 12.8 (8.3) |
Median (IQR) | 12.5 (7.0-19.3) |
12.6 (6.8-19.4) |
11.6 (6.1-18.4) |
11.7 (5.9-18.5) |
11.6 (6.1-18.4) |
11.7 (5.9-18.5) |
11.6 (6.1-18.4) |
11.7 (5.9-18.5) |
11.6 (6.1-18.4) |
11.7 (5.9-18.5) |
Incidence rate per 1000 person-years (95% CI) | 3.5 (3.4-3.7) |
3.5 (3.4-3.6) |
0.7 (0.7-0.8) |
0.9 (0.8-1.0) |
1.4 (1.2-1.5) |
1.3 (1.2-1.4) |
0.2 (0.1-0.2) |
0.2 (0.1-0.2) |
1.2 (1.1-1.3) |
1.1 (1.0-1.1) |
Hazard ratio (95% CI) | ||||||||||
Conditioneda | 1.30 (1.22-1.39) | 1.09 (0.94-1.26) | 1.36 (1.22-1.53) | 1.55 (1.14-2.11) | 1.32 (1.17-1.49) | |||||
Adjusted Ib | 1.21 (1.13-1.30) | 1.05 (0.91-1.23) | 1.27 (1.13-1.43) | 1.40 (1.01-1.95) | 1.16 (1.01-1.32) | |||||
Adjusted IIc | 1.26 (1.17-1.35) | 1.13 (0.96-1.33) | 1.26 (1.11-1.42) | 1.64 (1.15-2.34) | 1.24 (1.08-1.43) |
Indicates conditioned on family.
Indicates conditioned on family and further adjusted for education, Nordic country of birth, and time-dependent medical comorbidities (type 1 diabetes, autoimmune thyroid disease, rheumatoid arthritis, and inflammatory bowel disease).
Indicates conditioned on Adjusted I criteria and further adjusted for age and sex.