Table 1. Summary of Study Solutions and Fracture Populations.
| Trial name | Study population | Solution | Comparator | Minimum sample size, No. of patients |
|---|---|---|---|---|
| Aqueous-PREP | Patients with open appendicular fractures | 10% Povidone-iodine in purified water | 4% Chlorhexidine in purified water | 1540 |
| PREPAREa | Patients with open appendicular fractures | Iodine povacrylex 0.7% free iodine in 74% isopropyl alcohol | 2% Chlorhexidine in 70% isopropyl alcohol | 1540 |
| Patients with closed lower extremity and pelvic fractures | 6280 |
Abbreviations: Aqueous-PREP, Pragmatic Randomized Trial Evaluating Pre-Operative Aqueous Antiseptic Skin Solution in Open Fractures; PREPARE, Pragmatic Randomized Trial Evaluating Pre-Operative Alcohol Skin Solutions in Fractured Extremities.
a
Two separate study populations will be recruited and analyzed independently.