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The schematic view of molecular perturbances resulting in subsequent activation of the protein kinase RNA-like endoplasmic reticulum kinase (PERK)-dependent unfolded protein response (UPR) signaling pathway in the following neurodegenerative disorders: (A) Alzheimer’s disease (AD), (B) Parkinson’s disease (PD), (C) Huntington’s disease (HD), and (D) prion disease. More details are included in the text of the manuscript.
