Table 1.

LncRNAs deregulated in HCV viral cycle and antiviral response.

GENCODE Name	Alternative Name	HCV	Regulation	Impact	Role	Function	References
GAS5	-	Up		5′end blocks NS3	Blocks NS3	Antiviral	[71]
HOTAIR	-	Up	Core	Silences SIRT1 promoter and affects glucose and lipid metabolism	Viral release	Proviral	[74]
HULC	-	Up	RXRA	Required for lipid biogenesis. Facilitates binding of core with lipid droplets	Viral release	Proviral	[75]
IGF2-AS	-	Up	STAT3	Increases phosphatidylinositol 4-phosphate (PI4P)	Viral release	Proviral	[76]
7SK	-	Up	STAT3	Increases phosphatidylinositol 4-phosphate (PI4P)	Viral release	Proviral	[76]
AL391832.2	lncATV	Up	IFN	Binds to RIG-I and inhibits signaling and IFN production	Antiviral response	Proviral	[77]
CFAP58-DT	lncITPRIP-1	Up	IFN	Binds MDA5 and induces oligomerization, activation, and binding to viral RNA	Antiviral response	Antiviral	[20]
AL445490.1	lncRNA-IFI6	Up		Inhibits expression of neighbor IFI6, by affecting histone modification	Antiviral response	Proviral	[78]
BISPR	-	Up	IFN	Induces BST2 expression	Antiviral response	Antiviral	[79,80]
LUARIS	lncRNA-32		pI:C/down IFN	Binds ATF2 and induces ISG expression	Antiviral response	Antiviral	[81]
NRIR	lnc-CMPK2	Up	IFN	Negative regulator of several ISGs	Antiviral response	Proviral	[82]
GCSIR	lnc-ITM2C-1	Up	HCV/down IFN	Promotes expression of neighbor GPR55, negative regulator of ISGs	Antiviral response	Proviral	[83]
EGOT	-	Up	IFN/NF-κB	Negative regulator of several ISGs	Antiviral response	Proviral	[67]