Figure 8.

Summary and hypothetical mechanisms of age-related susceptibility to carbon tetrachloride (CCl₄) hepatotoxicity in weaning mice and adult mice. Higher metabolic rate of CCl₄ by hepatic CYP2E1 and CYP3A in weaning mice can cause excessive oxidative stress via reactive oxygen species (ROS) generation and glutathione (GSH) depletion, which can lead to significant liver injury. However, adult mice exhibit less CYP levels and high levels of GST-π and GR in their livers. This can contribute to resistance to CCl₄ hepatotoxicity.