Figure 2.

Signaling pathways deregulated during cytomegalovirus (CMV) infection. CMV may function as an oncomodulator to drive carcinogenesis. It seems to regulate the expression of proteins participating in cell proliferation, cell cycle arrest, cellular metabolism, apoptosis, angiogenesis, inflammation, immune suppression, and EMT plasticity [153,154,155,156,157,158,159,160,161]. It also codes for proteins that function as homologs for human proteins (such as chemokine receptors, Fc receptors, inhibitor of apoptosis).