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. 2020 Mar 5;12(3):602. doi: 10.3390/cancers12030602

Figure 1.

Figure 1

Classic immunopanels for clear-cell renal cell carcinoma (CCRCC). (A1,A2) cytokeratin 7 labeling is mostly negative but exceptionally positive in macrocystic tubules (arrow). (B1,B2) Carbonic anhydrase IX (CAIX) is always positive as a box pattern, which is a pathognomonic sign. (C1,C2) CAIX labeling tends to be stronger and more diffuse in higher grades (grade 3–4) than in lower ones (grade 1–2). (D1,D2) Alpha-methylacyl-CoA racemase is variably positive but less intense than in papillary renal cell carcinoma (PRCC). Adjuvant immunopanels of CCRCC. (E1,E2) In CCRCC, immunoreactivities of epithelial membrane antigen and CD10 are closely correlated. EMA is more exaggerated (E1) and CD10 expression occurs in a saw-tooth luminal pattern (E2). (F1,F2) EMA (F1) labeling recapitulates exaggerated CD10 (F2) expression. (G1–G3) E-cadherin expression is frequently lost (G1,G2) or occasionally broken (arrows) (G3). Scale bars = 1 mm.