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. 2020 Mar 5;12(3):602. doi: 10.3390/cancers12030602

Figure 2.

Figure 2

Papillary renal cell carcinoma (PRCC), type I. (A1,A2) Uniform structure predominantly composed of small slit-like tubules and luminal branched papillae is a characteristic of PRCC, type I. (B–E) PRCC type I is characteristically cytokeratin 7 (CK7)++ (B)/Alpha-methylacyl-CoA racemase (AMACR)++ (C)/CD10− (D)/carbonic anhydrase IX (CAIX)− (E). PRCC, type II. (F1,F2) PRCC type II differs from type I in larger and more complicated papillae line by taller larger cells. Aggregates of foamy histiocytes in the stroma of papillae are frequently noted. (G–K) Immunohistochemical (IHC) characteristic of PRCC, type II. PRCC, type II is usually CK7 negative (G), CAIX negative (H), epithelial membrane antigen+ (I) AMACR++ (J), and CD10++ (K1,K2). CD10 is basally distributed with a central sparing clubbing pattern (K2). Scale bars = 1 mm.