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. 2020 Mar 5;12(3):602. doi: 10.3390/cancers12030602

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Clear-cell papillary renal cell carcinoma. (A1–A4) In clear-cell papillary RCC (CCPRCC), histological findings include multilobulated small masses (A1) entirely composed of well-differentiated simple tubular structures mimicking distal tubules (A2) with intraluminal tufts (A3) and short papillary fronds in a glomeruloid pattern (A4). (B–D) Immunohistochemical profiles. Cytokeratin 7 is diffusely and strongly positive (B), Carbonic anhydrase IX is positive with cup-shaped pattern, (C), Alpha-methylacyl-CoA racemase is generally negative except for macrocystic spaces (D), and CD10 as a saw-tooth luminal pattern (E). Scale bars = 1 mm.