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. 2020 Mar 5;12(3):602. doi: 10.3390/cancers12030602

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Alteration of immunoprofiles in aggressive chromophobe renal cell carcinoma (ChRCC). (A1–A3) Aggressive behavior is uncommon in ChRCC, but few cases show metastasis and even rupture intestine (A1). Tumor cells lost the nature of ChRCC, showing sarcomatoid differentiation (A2) and marked anaplasia (A3) corresponding to International Society of Urological Pathology grade 4. (B1–B4) Altered immunoprofiles. The most remarkable findings are aberrant expression of CD10 (B1) and alpha-methylacyl-CoA racemase (B2) with cytokeratin 7 (B3) and c-kit (B4) preservation. Scale bars = 1 mm.