Table 3.
Additional hexapanels for adjunctive renal cell carcinoma subtyping.
| Subtype | CD10 | EMA | E-Cadherin | c-Kit | HNF-1β | Cathepsin K |
|---|---|---|---|---|---|---|
| CCRCC | 2+ (saw-tooth) | 1+ | 1+ (broken) | 0 | 2+ | 0 |
| PRCC I | 0 | 0 | 0 | 0 | 2+ | 0 |
| PRCC II | 2+(tram track) | 2+ | 0 | 0 | 2+ | 0 |
| CCPRCC | 1+ | 1+ | 1+ (broken) | 0 | 2+ | 0 |
| ChRCC | 0 | 2+(cytoplasm) | 2+ | 2+ | 0–1+ | 0 |
| RO | 0 | 2+(cytoplasm) | 2+ | 1+ | 2+ | 0 |
| MiT RCC | 0 | 0 | 1+ | 0 | 2+ | 2+ |
| CDC | 0 | 1+(cytoplasm) | 0–1+ (loss-broken) | 0 | 2+ | 0 |
Abbreviations: EMA, epithelial membrane antigen; HNF-1β, hepatocyte nuclear factor-1β; CCRCC, clear-cell renal cell carcinoma; PRCC, papillary renal cell carcinoma; ChRCC, chromophobe renal cell carcinoma; CCPRCC, clear-cell papillary renal cell carcinoma; RO, renal oncocytoma; MiT RCC: microphthalmos gene translocation-associated renal cell carcinoma; CDC, collecting duct carcinoma.