Figure 6.

Effect of ellagic acid, urolithin A, and urolithin B on the gene expression of glucose transporter type 4 (GLUT4), adiponectin, and leptin in 3T3-L1 adipocytes. The gene expression of GLUT4 with treatments at 25 µM (A), and gene expressions of adiponectin (B) and leptin with treatments at 25 and 50 µM (C) was determined by RT-PCR after 8 days of treatment with the compounds, as described in the Materials and Methods section. The values represent the mean ± SD (n = 3) of three independent experiments. Different letters among bars denote significant changes among treatments and control (p ≤ 0.05) performed by ANOVA and Tukey’s post hoc test.