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. 2020 Mar 18;21(6):2071. doi: 10.3390/ijms21062071

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The constructions and analysis of compound-target-pathway (CTP) network and the Protein-Protein Interaction (PPI) network of terpenes. (A) The candidate compounds with different pathological properties (good: Red diamond, moderate: Green diamond, week: Yellow diamond and N/A: Gray diamond), the ellipse nodes respect the KEGG enrichment terms with p < 0.01 (pink ellipse) and nodes not enriched in KEGG with p < 0.01 (blue ellipse), and AD-associated proteins (ellipse with red border) and the pathways (purple round rectangle) of Terpenes are constructed. (B) The protein-protein-interaction (PPI) network of Terpenes are illustrated with color by clusters and size by degree. Among these nodes, APP, ESR1, DRD2 and GRM2 are served as core targets with red border.