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. 2020 Mar 13;21(6):1965. doi: 10.3390/ijms21061965

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Differential gene expression analysis revealed hundreds of significant up- and downregulated genes in SCP1^GFP/SCX when compared to normal SCP1 (A). Furthermore, hierarchical cluster analysis of the 100 most differentially expressed genes clearly separates both cell lines (B). Gene ontology analysis of all significantly overexpressed genes in SCP1^GFP/SCX cells revealed several changes in biological functions (C) that also include collagen modifying genes, as well as released cytokines that are connected to cell migration (D). RNA-Seq data were obtained from three independent pellet preparations.