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. 2020 Mar 16;21(6):2012. doi: 10.3390/ijms21062012

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Altered expression of miRNAs and their biogenesis machinery in immune cells influencing both atherosclerosis and thrombosis processes in Antiphospholipid Syndrome and Systemic Lupus Erythematosus. miRNA expression profile is dysregulated in immune cells and plasma of APS and SLE patients. Those altered miRNAs could modulate the expression of inflammatory and CVD mediators, being associated with clinical pathological features of these diseases, such as atherosclerosis and thrombosis. The key role of the autoantibodies present in these diseases in the alteration of the miRNA profile has been confirmed indeed through in vitro studies.