Table 1.
Influence of diet on β-carotene-mediated UV-carcinogenic expression*.
| Diet | Median Tumor Time, Weeks | Tumors/Animal |
|---|---|---|
| Closed formula | ||
| Control | 20.6 | 0.52 |
| 0.07% β-Carotene | 20.0 | 0.60 |
| Semi-defined | ||
| Control | 19.5 | 0.60 |
| 0.07% β-Carotene | 17.2 | 1.63 |
* There was no significant influence of β-carotene on tumor latent period (median time to tumor) or tumor multiplicity (mean number of tumors/animal) in animals fed the closed-formula diet. Nor were there differences in either tumor parameter between closed-formula and semi-defined control diets. However, β-carotene supplementation of the semi-defined ration significantly shortened the tumor latent period (p < 0.002) and increased tumors (p < 0.03) [74].